Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes

作者全名：Cai, Mingming; Luo, Wangdu; Feng, Kevin; Chen, Yi; Yi, Lin; Zhu, Xiaomin; He, Ju; Liu, Hong; Hutnik, Cindy; Wang, Yong; Li, Xiangji; Xie, Lin

作者地址：[Cai, Mingming; Luo, Wangdu; Yi, Lin; Zhu, Xiaomin; He, Ju; Li, Xiangji; Xie, Lin] Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing 401120, Peoples R China; [Cai, Mingming] Chongqing Med Univ, Beibei Hosp, Dept Ophthalmol, Chongqing 400700, Peoples R China; [Feng, Kevin] Western Univ, Dept Basic Med Sci, London, ON, Canada; [Chen, Yi; Wang, Yong] Chongqing Univ, Natl Engn & Technol Res Ctr Magnesium Alloy Mat, Sch Mat Sci & Engn, Chongqing 400045, Peoples R China; [Liu, Hong; Hutnik, Cindy] Western Univ, Ivey Eye Inst, Dept Ophthalmol, St Josephs Hlth Care London, London, ON, Canada

通信作者：Li, XJ; Xie, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Dept Ophthalmol, Chongqing 401120, Peoples R China.

来源：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001254803300001

JCR分区：Q2

影响因子：4.2

年份：2024

卷号：35

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly leading to surgical failure. We developed a biodegradable material hydroxyapatite-coated magnesium (HA-Mg) as a glaucoma drainage device. Twelve New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (6 right eyes), trabeculectomy group (6 right eyes), and control group (12 left eyes). Results showed that all HA-Mg drainage plates were completely degraded similar to 4 months postoperatively. At the 5th month postoperatively, there was no statistical difference in the corneal endothelium density between the HA-Mg drainage plate group and the control group (p = 0.857). The intraocular pressure (IOP) level in the HA-Mg drainage plate implantation group was lower than in the other two groups. The trypan blue dye still drained from the anterior chamber to the subconjunctiva 5 months after HA-Mg drainage plate implantation. HE staining revealed the scleral linear aqueous humor drainage channel and anterior synechia were observed after drainage plate completely degraded, with no obvious infiltration with the inflammatory cells. This study showed the safety and efficacy of HA-Mg glaucoma drainage plate in controlling IOP after implantation into the anterior chamber of rabbit eyes. [GRAPHICS] .

基金机构：Natural Science Foundation of Chongqing [csts2018jcyjAX0016]; Senior Medical Talents Program of Chongqing for Young and Middle-aged; Foundation of The Third Affiliated Hospital, Chongqing Medical University [KY23052]

基金资助正文：This study was supported by the Natural Science Foundation of Chongqing (Grant No. csts2018jcyjAX0016), Senior Medical Talents Program of Chongqing for Young and Middle-aged, the Foundation of The Third Affiliated Hospital, Chongqing Medical University (Grant No. KY23052).