Novel therapeutic targets: bifidobacterium-mediated urea cycle regulation in colorectal cancer

作者全名:"Nie, Xusheng; Zhang, Tingting; Huang, Xiumei; Gu, Chongqi; Zuo, Wei; Fu, Li-Juan; Dong, Yiping; Liu, Hao"

作者地址:"[Nie, Xusheng] Yunyang Cty Peoples Hosp, Dept Gastroenterol, Chongqing 404599, Peoples R China; [Zhang, Tingting] Rongchang Dist Peoples Hosp, Dept Pediat, Chongqing 402460, Peoples R China; [Huang, Xiumei; Gu, Chongqi; Liu, Hao] Rongchang Dist Peoples Hosp Chongqing, Dept Digest, 3 North Guangchang Rd,Changyuan St, Chongqing 402460, Peoples R China; [Zuo, Wei; Fu, Li-Juan] Chongqing Med Univ, Sch Tradit Chinese Med, Dept Herbal Med, Chongqing 400016, Peoples R China; [Zuo, Wei; Fu, Li-Juan] Changsha Med Univ, Dept Pharmacol, Acad Workstn, Changsha 410219, Peoples R China; [Dong, Yiping] Army Med Univ, Dept Digital Med, Dept Bioengn & Imaging, Chongqing 400038, Peoples R China"

通信作者:"Liu, H (通讯作者),Rongchang Dist Peoples Hosp Chongqing, Dept Digest, 3 North Guangchang Rd,Changyuan St, Chongqing 402460, Peoples R China."

来源:CELL BIOLOGY AND TOXICOLOGY

ESI学科分类:MOLECULAR BIOLOGY & GENETICS

WOS号:WOS:001282982800001

JCR分区:Q1

影响因子:6.1

年份:2024

卷号:40

期号:1

开始页: 

结束页: 

文献类型:Article

关键词:Bifidobacterium Impact; Colorectal Cancer Metabolic Regulation; Urea Cycle Modulation; Ammonia Metabolic Control; ALB Gene Influence; Colorectal Cancer Microbiota Interaction

摘要:"Background and purposeColorectal cancer (CRC) is a widespread malignancy with a complex and not entirely elucidated pathogenesis. This study aims to explore the role of Bifidobacterium in the urea cycle (UC) and its influence on the progression of CRC, a topic not extensively studied previously.Experimental approachUtilizing both bioinformatics and experimental methodologies, this research involved analyzing bacterial abundance in CRC patients in comparison to healthy individuals. The study particularly focused on the abundance of BA. Additionally, transcriptomic data analysis and cellular experiments were conducted to investigate the impact of Bifidobacterium on ammonia metabolism and mitochondrial function, specifically examining its regulation of the key UC gene, ALB.Key resultsThe analysis revealed a significant decrease in Bifidobacterium abundance in CRC patients. Furthermore, Bifidobacterium was found to suppress ammonia metabolism and induce mitochondrial dysfunction through the regulation of the ALB gene, which is essential in the context of UC. These impacts contributed to the suppression of CRC cell proliferation, a finding corroborated by animal experimental results.Conclusions and implicationsThis study elucidates the molecular mechanism by which Bifidobacterium impacts CRC progression, highlighting its role in regulating key metabolic pathways. These findings provide potential targets for novel therapeutic strategies in CRC treatment, emphasizing the importance of microbiota in cancer progression."

基金机构:Chongqing Rongchang District People's Hospital 2022 the second batch of medical research Cultivation Fund Project

基金资助正文:No Statement Available