The role of immune cells and immune related genes in the tumor microenvironment of papillary thyroid cancer and their significance for immunotherapy

作者全名："Li, Xumei; Jian, Jie; Zhang, Anzhi; Xiang, Jiang ming; Huang, Jingjing; Chen, Yanlin"

作者地址："[Li, Xumei; Jian, Jie] Chongqing Changshou Dist Maternal & Child Hlth Hos, Dept Pathol, Chongqing, Peoples R China; [Zhang, Anzhi] Jiaxing Univ, Jiaxing Matern & Child Hlth Care Hosp, Dept Pathol, Affiliated Women & Childrens Hosp, Jiaxing, Peoples R China; [Xiang, Jiang ming; Huang, Jingjing] Chongqing Changshou Dist Maternal & Child Hlth Hos, Dept Surg, Chongqing, Peoples R China; [Chen, Yanlin] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Pathol, Women & Childrens Hosp, Chongqing, Peoples R China"

通信作者："Chen, YL (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Pathol, Women & Childrens Hosp, Chongqing, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001284942100018

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：PTC; Immune genes; Tumor microenvironment; CD40LG

摘要："Papillary thyroid carcinoma (PTC) is the most common pathological type of thyroid cancer (THCA) and shows a better prognosis than other types. However, further research is needed to determine the risk of PTC. We herein used the CIBERSORT algorithm to analyze the gene-expression profile obtained from TCGA, estimated the infiltration ratio of 22 immune cell types in tumor tissues and normal tissues, analyzed the differential expression of immune-related genes, and identified immune cells and immune-related genes related to clinical progress and prognosis. We uncovered 12 immune cell types and nine immune-related genes that were closely correlated with TNM staging, and two immune cell types (activated NK cells and gamma delta T cells) and one immune-related gene (CD40LG) that were associated with prognosis. After evaluation, four immune cell types could be used to determine low-risk PTC, with six immune cell types and six immune-related genes closely associated with high-risk PTC. The type and quantity of infiltrating immune cells in the microenvironment of PTC, as well as immune-related genes, appear to be closely related to tumor progression and can therefore be used as important indicators for the evaluation of patient prognosis. We posit that the study of immune cells and immune-related genes in the tumor microenvironment will facilitate the determination of low-risk PTC more accurately, and that this will greatly promote the development of high-risk PTC immunotherapy."

基金机构：Chongqing Changshou District Science and Technology Plan Project

基金资助正文：We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.