"Strategies, Challenges, and Prospects of Nanoparticles in Gynecological Malignancies"

作者全名："Zhang, Yingfeng; Tian, Jing"

作者地址："[Zhang, Yingfeng; Tian, Jing] Chongqing Med Univ, Univ Town Hosp, Chongqing 401331, Peoples R China"

通信作者："Tian, J (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Chongqing 401331, Peoples R China."

来源：ACS OMEGA

ESI学科分类：CHEMISTRY

WOS号：WOS:001298181600001

JCR分区：Q2

影响因子：4.1

年份：2024

卷号：9

期号：36

开始页：37459

结束页：37504

文献类型：Review

关键词：　

摘要："Gynecologic cancers are a significant health issue for women globally. Early detection and successful treatment of these tumors are crucial for the survival of female patients. Conventional therapies are often ineffective and harsh, particularly in advanced stages, necessitating the exploration of new therapy options. Nanotechnology offers a novel approach to biomedicine. A novel biosensor utilizing bionanotechnology can be employed for early tumor identification and therapy due to the distinctive physical and chemical characteristics of nanoparticles. Nanoparticles have been rapidly applied in the field of gynecologic malignancies, leading to significant advancements in recent years. This study highlights the significance of nanoparticles in treating gynecological cancers. It focuses on using nanoparticles for precise diagnosis and continuous monitoring of the disease, innovative imaging, and analytic methods, as well as multifunctional drug delivery systems and targeted therapies. This review examines several nanocarrier systems, such as dendrimers, liposomes, nanocapsules, and nanomicelles, for gynecological malignancies. The review also examines the enhanced therapeutic potential and targeted delivery of ligand-functionalized nanoformulations for gynecological cancers compared to nonfunctionalized anoformulations. In conclusion, the text also discusses the constraints and future exploration prospects of nanoparticles in chemotherapeutics. Nanotechnology will offer precise methods for diagnosing and treating gynecological cancers."

基金机构：Project of Science and Technology Research Project of Chongqing Education Commission [KJQN202200462]

基金资助正文："This work was funded by the project of Science and Technology Research Project of Chongqing Education Commission, KJQN202200462, study on the effect and mechanism of LncRNA RMST and Notch signaling pathway on trophoblast cells."