Clinical Characteristics of Overweight Patients With Acute Exacerbation Chronic Obstructive Pulmonary Disease (AECOPD)

作者全名："Gong, Yuxin; Du, Fawang; Yao, Yu; Wang, Hanchao; Wang, Xiaochuan; Xiong, Wei; Wang, Qin; He, Gaoyan; Chen, Linlin; Du, Heng; Yang, Juan; Bauer, Brent A.; Wang, Zhongruo; Deng, Huojin; Zhu, Tao"

作者地址："[Gong, Yuxin; Deng, Huojin] Southern Med Univ, Zhujiang Hosp, Dept Pulm & Crit Care Med, Guangzhou, Guangdong, Peoples R China; [Du, Fawang; Yao, Yu; Wang, Hanchao; Wang, Xiaochuan; He, Gaoyan; Zhu, Tao] Suining Cent Hosp, Dept Pulm & Crit Care Med, Suining, Sichuan, Peoples R China; [Xiong, Wei; Wang, Qin] Chongqing Med Univ, Affiliated Hosp 2, Dept Pulm & Crit Care Med, Chongqing, Peoples R China; [Chen, Linlin; Du, Heng] Suining Cent Hosp, Dept Gastroenterol Med, Suining, Sichuan, Peoples R China; [Yang, Juan; Bauer, Brent A.] Mayo Clin, Div Gen Internal Med, Rochester, MN USA; [Wang, Zhongruo] Univ Calif Davis, Dept Math, Davis, CA USA"

通信作者："Deng, HJ (通讯作者)，Southern Med Univ, Zhujiang Hosp, Dept Pulm & Crit Care Med, Guangzhou, Guangdong, Peoples R China.; Zhu, T (通讯作者)，Suining Cent Hosp, Dept Pulm & Crit Care Med, Suining, Sichuan, Peoples R China."

来源：CLINICAL RESPIRATORY JOURNAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001298580600001

JCR分区：Q3

影响因子：1.7

年份：2024

卷号：18

期号：8

开始页：　

结束页：　

文献类型：Article

关键词：chronic obstructive pulmonary disease (COPD); hypertension; nomogram; overweight; type 2 diabetes (T2DM)

摘要："Introduction: Low body weight in patients with COPD is associated with a poor prognosis and more comorbidities. However, the impact of increased body weight in patients with COPD remains controversial. The aim of this study was to explore the clinical features of overweight patients with AECOPD. Methods: In this multicenter cross-sectional study, a total of 647 AECOPD patients were recruited. Finally, 269 normal weight and 162 overweight patients were included. Baseline characteristics and clinical and laboratory data were collected. The least absolute shrinkage and selection operator (LASSO) regression was performed to determine potential features, which were substituted into binary logistic regression to reveal overweight-associated clinical features. The nomogram and its associated curves were established to visualize and verify the logistic regression model. Results: Six potential overweight-associated variables were selected by LASSO regression. Subsequently, a binary logistic regression model identified that the rates of type 2 diabetes (T2DM) and hypertension and levels of lymphocytes (LYM)%, and alanine aminotransferase (ALT) were independent variables of overweight in AECOPD patients. The C-index and AUC of the ROC curve of the nomogram were 0.671 and 0.666, respectively. The DCA curve revealed that the nomogram had more clinical benefits if the threshold was at a range of 0.22 similar to 0.78. Conclusions: Collectively, we revealed that T2DM and hypertension were more common, and LYM% and ALT were higher in AECOPD patients with overweight than those with normal weight. The result suggests that AECOPD patients with overweight are at risk for additional comorbidities, potentially leading to worse outcomes."

基金机构："Chongqing Health Joint Medical Research Project [2020MSXM112, 2020FYYX17]; National Natural Science Foundation of China (Youth Program) [8180011074]; Natural Sciences Foundation of Sichuan [23NSFSC0667]; Health Commission Technology Project of Sichuan [23LCYJ008]; Respiratory Diseases Youth Practical Research Project of China International Medical Exchange Foundation [Z-2017-24-2301]"

基金资助正文："This study was supported by the Chongqing Health Joint Medical Research Project (2020MSXM112 and 2020FYYX17), the National Natural Science Foundation of China (Youth Program) (8180011074), the Natural Sciences Foundation of Sichuan (23NSFSC0667), the Health Commission Technology Project of Sichuan (23LCYJ008), and Respiratory Diseases Youth Practical Research Project of China International Medical Exchange Foundation (Z-2017-24-2301)."