The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20-59: a population-based study in the United States

作者全名："Hao, Jia-qi; Zhuang, Zi-xuan; Hu, Shu-yue; Zhang, Yu-jie; Zhang, Jia-wan; He, Feng-Jun; Wang, Rui; Zhuang, Wen; Wang, Mo-jin"

作者地址："[Hao, Jia-qi; Zhang, Yu-jie; Zhang, Jia-wan; He, Feng-Jun; Zhuang, Wen; Wang, Mo-jin] Sichuan Univ, West China Hosp, Gastr Canc Ctr, Chengdu, Sichuan, Peoples R China; [Zhuang, Zi-xuan] Sichuan Univ, West China Hosp, Colorectal Canc Ctr, Chengdu, Sichuan, Peoples R China; [Hao, Jia-qi; Zhuang, Zi-xuan; Zhang, Yu-jie; Zhang, Jia-wan; He, Feng-Jun; Zhuang, Wen; Wang, Mo-jin] Sichuan Univ, West China Hosp, Dept Gen Surg, Chengdu, Sichuan, Peoples R China; [Wang, Rui] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu, Sichuan, Peoples R China; [Hu, Shu-yue] Chongqing Med Univ, Childrens Hosp, Neonatol Dept, Chongqing, Peoples R China"

通信作者："Wang, MJ (通讯作者)，Sichuan Univ, West China Hosp, Gastr Canc Ctr, Chengdu, Sichuan, Peoples R China.; Wang, MJ (通讯作者)，Sichuan Univ, West China Hosp, Dept Gen Surg, Chengdu, Sichuan, Peoples R China."

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001300716000003

JCR分区：Q2

影响因子：4.5

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：NHHR; Appendicular lean mass (ALM); Sarcopenia; NHANES; Cross-sectional study

摘要："BackgroundThe ratio between non-high-density lipoprotein cholesterol and high-density lipoprotein cholesterol (NHHR) is a reliable marker for assessing the risk linked to lipid metabolism disorders. Sarcopenia, characterized by age-related loss of muscle mass and strength/function, includes the assessment of muscle mass, muscle strength, and muscle-specific strength. However, research into NHHR's relationship with low muscle mass risk remains unexplored.MethodsOur study utilized a cross-sectional approach, examining data derived from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Through multivariable linear and logistic regression, we investigated the relationships of the NHHR with muscle mass and low muscle mass. We visualized the results using smoothing curves and assessed threshold effects. We also performed various subgroup and sensitivity analyses.ResultsThis research encompassed 9,012 participants and demonstrated significant nonlinear associations between NHHR and ALMBMI or low muscle mass risk in a generalized additive model (GAM), pinpointing critical NHHR values (3.328 and 3.367) where changes in NHHR significantly impacted ALMBMI and low muscle mass risk.ConclusionsThe NHHR demonstrates a significant association with an increased risk of low muscle mass among middle-aged Americans. This ratio has potential as a predictive marker for low muscle mass. Further exploration of NHHR is expected to aid in advancing preventive and therapeutic measures for this condition."

基金机构：Sichuan Province Science and Technology Support Program

基金资助正文："We express our gratitude to the personnel at the National Center for Health Statistics of the Centers for Disease Control for their efforts in designing, collecting, and compiling the NHANES data, as well as for establishing the public database."