Advancements in NMN biotherapy and research updates in the field of digestive system diseases

作者全名："Liao, Guanyi; Xie, Yuchen; Peng, Hong; Li, Tianke; Zou, Xinsen; Yue, Faguo; Guo, Jinjun; Rong, Li"

作者地址："[Liao, Guanyi; Xie, Yuchen; Peng, Hong; Li, Tianke; Guo, Jinjun; Rong, Li] Chongqing Med Univ, Bishan Hosp Chongqing, Dept Gastroenterol, Bishan Hosp, Chongqing, Peoples R China; [Zou, Xinsen] Chongqing Med Univ, Bishan Hosp, Bishan Hosp Chongqing, Dept Intens Unit Care, Chongqing, Peoples R China; [Yue, Faguo] Chongqing Med Univ, Bishan Hosp Chongqing, Sleep & Psychol Ctr, Bishan Hosp, Chongqing, Peoples R China"

通信作者："Guo, JJ; Rong, L (通讯作者)，Chongqing Med Univ, Bishan Hosp Chongqing, Dept Gastroenterol, Bishan Hosp, Chongqing, Peoples R China."

来源：JOURNAL OF TRANSLATIONAL MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001302460500002

JCR分区：Q1

影响因子：7.4

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Nicotinamide adenine dinucleotide (NAD); Nicotinamide mononucleotide (NMN); Biological therapy; Animal experiments; Clinical trials; Digestive system diseases

摘要："Nicotinamide mononucleotide (NMN), a crucial intermediate in NAD + synthesis, can rapidly transform into NAD + within the body after ingestion. NMN plays a pivotal role in several important biological processes, including energy metabolism, cellular aging, circadian rhythm regulation, DNA repair, chromatin remodeling, immunity, and inflammation. NMN has emerged as a key focus of research in the fields of biomedicine, health care, and food science. Recent years have witnessed extensive preclinical studies on NMN, offering valuable insights into the pathogenesis of age- and aging-related diseases. Given the sustained global research interest in NMN and the substantial market expectations for the future, here, we comprehensively review the milestones in research on NMN biotherapy over the past 10 years. Additionally, we highlight the current research on NMN in the field of digestive system diseases, identifying existing problems and challenges in the field of NMN research. The overarching aim of this review is to provide references and insights for the further exploration of NMN within the spectrum of digestive system diseases."

基金机构：Natural Science Foundation of Chongqing Municipality

基金资助正文："The authors would like to thank all the reviewers who participated in the review, as well as MJEditor (www.mjeditor.com) for providing English editing services during the preparation of this manuscript."