Liver Function-Related Indicators and Risk of Gallstone Diseases-A Multicenter Study and a Systematic Review and Meta-Analysis

作者全名："Li, Shiyi; Zhu, Pei; Chen, Fangyuan; Yu, Wenqian; Xie, Linjun; Xia, Jing; Jiao, Peng; Cui, Ping; Zhang, Chi; Bai, Ye; Jiang, Guoheng; Li, Hongyu; Lou, Yanmei; Li, Guangcan; Shan, Xuefeng; Wang, Xin"

作者地址："[Li, Shiyi; Yu, Wenqian; Xie, Linjun; Xia, Jing; Jiang, Guoheng; Li, Hongyu; Wang, Xin] Sichuan Univ, West China Sch Publ Hlth, South Renmin Rd, Chengdu 610041, Peoples R China; [Zhu, Pei] Mianyang City Ctr Dis Control & Prevent, Dept Vaccine Clin Res Inst, Mianyang, Sichuan, Peoples R China; [Chen, Fangyuan] Gen Hosp Western War Zone Chinese Peoples Liberat, Mil Casualty Management Dept, Chengdu 610036, Peoples R China; [Jiao, Peng] Jining 1 Peoples Hosp Jining, Dept Hlth Management, Jining, Shandong, Peoples R China; [Cui, Ping] Jining Med Univ, Dept Publ Hlth, Jining 272067, Peoples R China; [Zhang, Chi] Tianjin Med Univ Canc Inst & Hosp, Dept Prevent, Tianjin 300060, Peoples R China; [Bai, Ye] Jilin Univ, Bethune Hosp 1, Clin Pathol Diag Ctr, Changchun 130000, Jilin, Peoples R China; [Lou, Yanmei] Beijing Xiaotangshan Hosp, Dept Hlth Management, Beijing 102211, Peoples R China; [Li, Guangcan] Peoples Hosp Kaizhou Dist, Dept Pharm, 8 Ankang Rd,Hanfeng St, Chongqing 405400, Peoples R China; [Shan, Xuefeng] Chongqing Med Univ, Dept Pharm, Bishan Hosp, Chongqing 402760, Peoples R China"

通信作者："Wang, X (通讯作者)，Sichuan Univ, West China Sch Publ Hlth, South Renmin Rd, Chengdu 610041, Peoples R China."

来源：GASTROENTEROLOGY RESEARCH AND PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001303321900001

JCR分区：Q4

影响因子：2

年份：2024

卷号：2024

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：gallstone disease; liver function-related indicators; multicenter cross-sectional study; systematic review and meta-analysis

摘要："Purpose of the study: We aim to examine the association between liver function-related indicators and gallstone disease (GSD) risk.Study design: The subjects who participated in the China Multicenter Physical Examination Cohort (CMPEC) were enrolled. Relative odds ratios (ORs) with 95% CIs and standardized mean differences (SMDs) were applied to investigate the effect of liver function-related indicators and GSD risk. Moreover, a systematic review and meta-analysis were conducted until July 2021. Additionally, the results in the CMPEC and the systematic review and meta-analysis were combined by meta-analysis. Finally, the results were validated by a cohort study of the UK Biobank (UKB).Results and conclusions: Totally, 369,931 subjects in CMPEC were included in the study. A total of 28 publications were incorporated into the systematic review and meta-analysis. The pooled analysis suggested that aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), and low albumin (ALB) were positively associated with the risk of GSD. Meanwhile, GSD present to have higher AST, ALT, gamma-glutamyl transferase (GGT), total bilirubin (TBil), globulin (G), and ALP levels and relatively lower TP and ALB levels than the healthy participants. These results were consistent when stratified by the study design, geographic background, and study quality. Only the association between ALP and GSD risk was validated in the UKB cohort. This study suggests liver function indicators were associated with GSD risk. The results may provide the basis for exploring the etiology of GSD and may help clinicians identify high-risk subjects.Trial Registration: PROSPERO (CRD42020179076)."

基金机构：Sichuan Provincial Science and Technology Department 2023 Central Guide Local Project

基金资助正文：The authors have nothing to report.