DNA damage response and inflammatory response: Two traffic lights for HPVs on the road to transformation

作者全名："Liu, Yanfei; Niu, Mengda; Luo, Ying; Pan, Min; Hong, Shiyuan"

作者地址："[Liu, Yanfei; Niu, Mengda; Luo, Ying; Hong, Shiyuan] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Pan, Min] Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Chongqing, Peoples R China"

通信作者："Hong, SY (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.; Pan, M (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Chongqing, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001304602800026

JCR分区：Q1

影响因子：12.7

年份：2024

卷号：96

期号：8

开始页：　

结束页：　

文献类型：Review

关键词：cervical cancer; DNA damage response; head and neck squamous cell carcinoma; HPV replication; inflammatory response

摘要："Human papillomaviruses (HPVs) are non-enveloped double-stranded DNA viruses. When HPV infection persists, infected tissues can develop many HPV-related diseases such as cervical cancer and head and neck squamous cell carcinoma. To establish their persistent infection, HPVs have evolved mechanisms to manipulate the host cellular processes such as DNA damage response (DDR), which includes homologous recombination, nonhomologous end joining, and microhomology-mediated end joining. Additionally, HPVs utilize host inflammatory processes to facilitate their life cycles. Here, we bridge the concepts of DDR and inflammatory response, and discuss how HPV proteins orchestrate a sophisticated manipulation of DDR and inflammation to promote their viral replication, ultimately fostering the progression of infected cells towards oncogenic transformation to malignancy."

基金机构：CQMU Program for Youth Innovation in Future Medicine [172020320220090]; Chongqing Yuzhong District Basic Research and Frontier Exploration Project [20210128]; Entrepreneurship and Innovation Support Programme for Overseas Talents of the Human Resources and Social Security Bureau of Chongqing [203011220230010]; Swedish Heart-Lung Foundation [20210128] Funding Source: Swedish Heart-Lung Foundation

基金资助正文："CQMU Program for Youth Innovation in Future Medicine, Grant/Award Number: 172020320220090; Chongqing Yuzhong District Basic Research and Frontier Exploration Project, Grant/Award Number: 20210128; Entrepreneurship and Innovation Support Programme for Overseas Talents of the Human Resources and Social Security Bureau of Chongqing, Grant/Award Number: 203011220230010."