Differences in the Intestinal Flora of Patients with Inflammatory Bowel Disease in Southwest China

作者全名："Wang, Tingting; Yu, Renlin; Zhu, Lingling; Wang, Xuean; Yang, Bin"

作者地址："[Wang, Tingting; Zhu, Lingling; Wang, Xuean; Yang, Bin] Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Peoples R China; [Yu, Renlin] Chongqing Med Univ, Dept Clin Lab, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Yang, B (通讯作者)，Sichuan Univ, Dept Lab Med, West China Hosp, Chengdu, Peoples R China."

来源：INDIAN JOURNAL OF MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000772698900001

JCR分区：Q3

影响因子：3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Inflammatory bowel disease; Intestinal flora; 16S rRNA gene; Southwest China; Alpha diversity; Beta diversity

摘要："To study changes in the intestinal flora associated with inflammatory bowel disease (IBD) in the Han population of southwest China, 48 participants were enrolled, 18 of whom had been diagnosed with IBD. Stool samples were collected from the participants. Sequencing of 16S rRNA gene was used to measure and identify the components of the intestinal flora. Diversity analysis and multivariate statistical analysis were conducted to study differences in intestinal flora between patients with IBD and healthy controls. The goods coverage, observed species, Shannon, and Simpson indices of alpha diversity were different (p < 0.05). Beta diversity analysis yielded significant differences between groups (R = 0.5668, p = 0.001 < 0.05). Compared with the composition of the intestinal flora in healthy controls, the relative abundances of Proteobacteria (18.56% vs. 3.56%, p = 0.001) and Fusobacterium (2.08% vs. 0.35%, p = 0.005) were higher in patients with IBD. Therefore, this study provides insight into the role of the microbiome in IBD."

基金机构："National Natural Science Foundation of China [81772258]; Science and Technology Agency of Sichuan Province [2019YFS0310, 2018FZ0106]"

基金资助正文："This study was funded by the National Natural Science Foundation of China (No. 81772258) and Science and Technology Agency of Sichuan Province (2019YFS0310, 2018FZ0106)."