"The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A"

作者全名："Fu, Jiajia; Huang, Yan; Bao, Ting; Liu, Chengcheng; Liu, Xi; Chen, Xueping"

作者地址："[Fu, Jiajia; Chen, Xueping] Sichuan Univ, West China Hosp, Dept Neurol, Wai Nan Guo Xue Xiang 37, Chengdu, Sichuan, Peoples R China; [Huang, Yan; Bao, Ting] Sichuan Univ, West China Hosp, Management Ctr, Chengdu, Sichuan, Peoples R China; [Liu, Chengcheng] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,Dept Periodont, Chengdu, Sichuan, Peoples R China; [Liu, Xi] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing, Peoples R China"

通信作者："Chen, XP (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurol, Wai Nan Guo Xue Xiang 37, Chengdu, Sichuan, Peoples R China."

来源：JOURNAL OF NEUROINFLAMMATION

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000787056900001

JCR分区：Q1

影响因子：9.3

年份：2022

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：TH17; IL-17A; Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; Targeted therapy

摘要："Neurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Immune pathway dysregulation is one of the common features of neurodegeneration. Recently, there is growing interest in the specific role of T helper Th 17 cells and Interleukin-17A (IL-17A), the most important cytokine of Th 17 cells, in the pathogenesis of the central nervous system (CNS) of neurodegenerative diseases. In the present study, we summarized current knowledge about the function of Th17/IL-17A, the physiology of Th17/IL-17A in diseases, and the contribution of Th17/IL-17A in AD, PD, and ALS. We also update the findings on IL-17A-targeting drugs as potentially immunomodulatory therapeutic agents for neurodegenerative diseases. Although the specific mechanism of Th17/IL-17A in this group of diseases is still controversial, uncovering the molecular pathways of Th17/IL-17A in neurodegeneration allows the identification of suitable targets to modulate these cellular processes. Therapeutics targeting IL-17A might represent potentially novel anti-neurodegeneration drugs."

基金机构：National key Research and development program of China [2017YFC09007703]; science and technology planning project in Sichuan Province [2020YJ0281]; 1.3.5 project for disciplines of excellence West China Hospital Sichuan University [ZYJC18038]; cadres health care project in Sichuan Province [2019-112]

基金资助正文："This study was supported by grant from National key Research and development program of China (Grant No. 2017YFC09007703), grant from science and technology planning project in Sichuan Province (Grant No. 2020YJ0281), grant from 1 center dot 3 center dot 5 project for disciplines of excellence West China Hospital Sichuan University (Grant No. ZYJC18038), and the grant from cadres health care project in Sichuan Province (Grant No. 2019-112)."