The Chinese Parkinson's Disease Registry (CPDR): Study Design and Baseline Patient Characteristics

作者全名："Zhou, Xiaoxia; Liu, Zhenhua; Zhou, Xiaoting; Xiang, Yaqin; Zhou, Zhou; Zhao, Yuwen; Pan, Hongxu; Xu, Qian; Chen, Yase; Sun, Qiying; Wu, Xinyin; Tan, Hongzhuan; Li, Bin; Yuan, Kai; Xie, Yali; Liao, Weihua; Hu, Shuo; Zhu, Jianping; Wu, Xuehong; Li, Jianhua; Wang, Chunyu; Lei, Lifang; Tang, Jiayu; Liu, Yonghong; Wu, Heng; Huang, Wei; Wang, Tao; Xue, Zheng; Wang, Puqing; Zhang, Zhentao; Xu, Ping; Chen, Ling; Wang, Qing; Wang, Xuejing; Cheng, Oumei; Shen, Yuefei; Liu, Weiguo; Ye, Min; You, Yong; Li, Jinchen; Yan, Xinxiang; Guo, Jifeng; Tang, Beisha"

作者地址："[Zhou, Xiaoxia; Liu, Zhenhua; Zhou, Xiaoting; Xiang, Yaqin; Zhou, Zhou; Zhao, Yuwen; Pan, Hongxu; Xu, Qian; Chen, Yase; Sun, Qiying; Yan, Xinxiang; Guo, Jifeng; Tang, Beisha] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China; [Liu, Zhenhua; Sun, Qiying; Li, Bin; Yuan, Kai; Xie, Yali; Li, Jinchen; Yan, Xinxiang; Guo, Jifeng; Tang, Beisha] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China; [Liu, Zhenhua; Li, Jinchen; Guo, Jifeng; Tang, Beisha] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha, Hunan, Peoples R China; [Liu, Zhenhua; Li, Jinchen; Guo, Jifeng; Tang, Beisha] Cent South Univ, Hunan Key Lab Med Genet, Sch Life Sci, Changsha, Hunan, Peoples R China; [Liu, Zhenhua; Li, Jinchen; Guo, Jifeng; Tang, Beisha] Cent South Univ, Key Lab Hunan Prov Neurodegenerat Disorders, Changsha, Hunan, Peoples R China; [Wu, Xinyin; Tan, Hongzhuan] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China; [Liao, Weihua] Cent South Univ, Xiangya Hosp, Dept Radiol, Changsha, Hunan, Peoples R China; [Hu, Shuo] Xiangya Hosp Cent South Univ, Dept Nucl Med PET Ctr, Changsha, Hunan, Peoples R China; [Zhu, Jianping; Wu, Xuehong] Hunan KeY Hlth Technol Co Ltd, Changsha, Hunan, Peoples R China; [Li, Jianhua] Hunan Creator Informat Technol Co Ltd, Changsha, Hunan, Peoples R China; [Wang, Chunyu] Cent South Univ, Xiangya Hosp 2, Dept Neurol, Changsha, Hunan, Peoples R China; [Lei, Lifang] Cent South Univ, Xiangya Hosp 3, Dept Neurol, Changsha, Hunan, Peoples R China; [Tang, Jiayu] Hunan Prov Brain Hosp, Dept Neurol, Changsha, Hunan, Peoples R China; [Liu, Yonghong] Hunan Prov Brain Hosp, Hlth Management Ctr, Changsha, Hunan, Peoples R China; [Wu, Heng] Univ South China, Dept Neurol, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China; [Huang, Wei] Nanchang Univ, Dept Neurol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China; [Wang, Tao] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Hubei, Peoples R China; [Xue, Zheng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Hubei, Peoples R China; [Wang, Puqing] Hubei Univ Med, Dept Neurol, Xiang Yang 1 Peoples Hosp, Xiangyang, Hubei, Peoples R China; [Zhang, Zhentao] Wuhan Univ, Dept Neurol, Renmin Hosp, Wuhan, Hubei, Peoples R China; [Xu, Ping] Zunyi Med Univ, Dept Neurol, Affiliated Hosp, Zunyi, Guizhou, Peoples R China; [Chen, Ling] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Guangdong, Peoples R China; [Wang, Qing] Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Guangdong, Peoples R China; [Wang, Xuejing] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China; [Cheng, Oumei] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Shen, Yuefei] Guangxi Med Univ, Dept Neurol, Affiliated Hosp 1, Nanning, Peoples R China; [Liu, Weiguo] Nanjing Med Univ, Dept Neurol, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China; [Ye, Min] Nanjing Med Univ, Dept Neurol, Affiliated BenQ Hosp, Nanjing, Jiangsu, Peoples R China; [You, Yong] Hainan Med Univ, Affiliated Hosp 2, Dept Neurol, Haikou, Hainan, Peoples R China"

通信作者："Guo, JF; Tang, BS (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China."

来源：MOVEMENT DISORDERS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000789888400001

JCR分区：Q1

影响因子：8.6

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Parkinson's disease; natural history; longitudinal; CPDR; PD-MDCNC

摘要："Background There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history of PD in China. Objectives The objective of this study was to launch the Chinese Parkinson's Disease Registry (CPDR) and to report its protocol, cross-sectional baseline data, and prospects for a comprehensive observational, longitudinal, multicenter study. Methods The CPDR recruited PD patients from 19 clinical sites across China between January 2018 and December 2020. Clinical data were collected prospectively using at least 17 core assessment scales. Patients were followed up for clinical outcomes through face-to-face interviews biennially. Results We launched the CPDR in China based on the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network (PD-MDCNC). A total of 3148 PD patients were enrolled comprising 1623 men (51.6%) and 1525 women (48.4%). The proportions of early-onset PD (EOPD, age at onset <= 50 years) and late-onset PD (LOPD) were 897 (28.5%) and 2251 (71.5%), respectively. Stratification by age at onset showed that EOPD manifested milder motor and nonmotor phenotypes and was related to increased probability of dyskinesia. Comparison across genders suggested a slightly older average age at PD onset, milder motor symptoms, and a higher rate of developing levodopa-induced dyskinesias in women. Conclusions The CPDR is one of the largest multicenter, observational, longitudinal, and natural history studies of PD in China. It offers an opportunity to expand the understanding of clinical features, genetic, imaging, and biological markers of PD progression. (c) 2022 International Parkinson and Movement Disorder Society."

基金机构：National Key Plan for Scientific Research and Development of China [2016YFC1306000]; Hunan Innovative Province Construction Project [2019SK2335]

基金资助正文：This study was supported by grants from the National Key Plan for Scientific Research and Development of China (Grant No. 2016YFC1306000) and Hunan Innovative Province Construction Project (Grant No. 2019SK2335).