Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/Wnt/beta-catenin signaling axis

作者全名:"Cheng, Zhaobo; Yu, Renjie; Li, Li; Mu, Junhao; Gong, Yijia; Wu, Fan; Liu, Yujia; Zhou, Xiangyi; Zeng, Xiaohua; Wu, Yongzhong; Sun, Ran; Xiang, Tingxiu"

作者地址:"[Cheng, Zhaobo; Yu, Renjie; Liu, Yujia; Zhou, Xiangyi; Xiang, Tingxiu] Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China; [Cheng, Zhaobo; Yu, Renjie; Li, Li; Mu, Junhao; Gong, Yijia; Wu, Fan; Sun, Ran] Chongqing Med Univ, Chongqing Key Lab Mol Oncol & Epigenet, Affiliated Hosp 1, Chongqing, Peoples R China; [Zeng, Xiaohua; Wu, Yongzhong; Xiang, Tingxiu] Chongqing Univ Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing 400030, Peoples R China"

通信作者:"Xiang, TX (通讯作者),Chongqing Med Univ, Dept Oncol, Affiliated Hosp 1, Chongqing, Peoples R China.; Sun, R (通讯作者),Chongqing Med Univ, Chongqing Key Lab Mol Oncol & Epigenet, Affiliated Hosp 1, Chongqing, Peoples R China.; Xiang, TX (通讯作者),Chongqing Univ Canc Hosp, Chongqing Key Lab Translat Res Canc Metastasis &, Chongqing 400030, Peoples R China."

来源:CELLULAR AND MOLECULAR LIFE SCIENCES

ESI学科分类:MOLECULAR BIOLOGY & GENETICS

WOS号:WOS:000790817300003

JCR分区:Q2

影响因子:8

年份:2022

卷号:79

期号:5

开始页: 

结束页: 

文献类型:Article

关键词:Breast cancer; ZNF334; Wnt; beta-catenin; SFRP1; Transcription factor

摘要:"Zinc-finger proteins (ZNFs) constitute the largest transcription factor family in the human genome. The family functions in many important biological processes involved in tumorigenesis. In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancery (BrCa) tissues and TNBC cell lines MDA-MB-231 (MB231) and YCCB1. We observed that promoter hypermethylation of ZNF334 was common in BrCa cell lines and tissues, which was likely responsible for its reduced expression. Ectopic expression of ZNF334 in TNBC cell lines MB231 and YCCB1 could suppress their growth and metastatic capacity both in vitro and in vivo, and as well induce cell cycle arrest at S phase and cell apoptosis. Moreover, re-expression of ZNF334 in TNBC cell lines could rescue Epithelial-Mesenchymal Transition (EMT) process and restrain stemness, due to up-regulation of SFRP1, which is an antagonist of Wnt/beta-catenin signaling. In conclusion, we verified that ZNF334 had a suppressive function of TNBC cell lines by targeting the SFRP1/Wnt/beta-catenin signaling axis, which might have the potentials to become a new biomarker for diagnosis and treatment of TNBC patients."

基金机构:"National Natural Science Foundation of China [81872380, 82172619]; Natural Science Foundation of Chongqing [cstc2019jcjy-msxmX0861, cstc2020jcyj-bshX0025]; Postdoctoral Science Foundation of China [2020M683262]"

基金资助正文:"This study was supported by the National Natural Science Foundation of China (#81872380, #82172619), Natural Science Foundation of Chongqing (cstc2019jcjy-msxmX0861, cstc2020jcyj-bshX0025), Postdoctoral Science Foundation of China (2020M683262)."