Utility of a Patient-Reported Symptom and Functioning Assessment Tool for Geriatric Oncology Care in China

作者全名："Xue, Dong; Li, Pingping; Chen, Tsun Hsuan; Shi, Qiuling; Wang, Xin Shelley"

作者地址："[Xue, Dong; Li, Pingping] Beijing Canc Hosp, Dept Integrated Chinese & Western Med & Geriatr O, 52 Fucheng Rd, Beijing, Peoples R China; [Chen, Tsun Hsuan; Wang, Xin Shelley] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Unit 1450,1515 Holcombe Blvd, Houston, TX 77030 USA; [Shi, Qiuling] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China"

通信作者："Li, PP (通讯作者)，Beijing Canc Hosp, Dept Integrated Chinese & Western Med & Geriatr O, 52 Fucheng Rd, Beijing, Peoples R China.; Wang, XS (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Unit 1450,1515 Holcombe Blvd, Houston, TX 77030 USA."

来源：VALUE IN HEALTH REGIONAL ISSUES

ESI学科分类：　

WOS号：WOS:000792105100005

JCR分区：Q3

影响因子：2

年份：2022

卷号：29

期号：　

开始页：28

结束页：35

文献类型：Article

关键词：functioning status; geriatric oncology; MD Anderson Symptom Inventory (MDASI); patiemt-reported outcomes (PROs); symptom assessment; validation

摘要："Objectives: Symptom and functional assessment is challenging in geriatric oncology care. This multicenter cross-sectional study examined the use of a multiple-symptom assessment tool, the MD Anderson Symptom Inventory (MDASI), on Chinese patients with cancer aged 65 years and older.Methods: Patient-rated symptoms and functioning were assessed using MDASI and the European Organization for Research and Treatment of Cancer quality-of-life questionnaire.Results: The most severe symptoms were fatigue and poor appetite. The older group (75-84 years old, n = 224) reported a more severe difficulty remembering (effect size [ES] 0.32; P<.001), shortness of breath (ES 0.20; P=.020), and interference with general activity (ES 0.14; P=.027), with significantly worse physical functioning (ES 20.33; P<.001) and cognitive functioning on the European Organization for Research and Treatment of Cancer quality-of-life questionnaire (ES 0.20; P<.001) than the younger group (65-74 years old, n = 555). For MDASI measures of the core symptoms and total interference with daily activity, Cronbach a coefficients were 0.90 and 0.93, respectively, for the younger group; and 0.93 and 0.94 for the older group, respectively. Moderate to severe (score $4) interference with general activity and walking on MDASI accurately indicated poor performance status (area under the curve 0.8089 and 0.7969, respectively) and lack of independence status of Activities of Daily Living (area under the curve 0.7993 and 0.8304, respectively). Conclusions: MDASI is psychometrically reliable, valid, and clinically sensitive for the measuring symptom burden and functional status of Chinese patients with cancer aged 65 years and older. MDASI could be adopted to measure multiple symptoms and physical functioning outcomes in geriatric oncology practice as well as for research on treatment benefits."

基金机构："Integrative Medicine Research, Beijing Chinese Medicine Bureau; Key Program Foundation of Beijing Administration of Traditional Chinese Medicine"

基金资助正文："This work was supported by an award to Dr Li from Integrative Medicine Research, Beijing Chinese Medicine Bureau, as well as by grants from the Key Program Foundation of Beijing Administration of Traditional Chinese Medicine to Dr Li."