The pro-inflammatory effect of triglyceride on human CD4(+) T cells and experimental autoimmune uveitis

作者全名:"Tan, Shiyao; Feng, Xiaojie; Liu, Zhangluxi; Wang, Qingfeng; Jiang, Qingyan; Ye, Xingsheng; Li, Hongxi; Su, Guannan; Zhou, Chunjiang; Wang, Yao; Yang, Peizeng"

作者地址:"[Tan, Shiyao; Feng, Xiaojie; Liu, Zhangluxi; Wang, Qingfeng; Jiang, Qingyan; Ye, Xingsheng; Li, Hongxi; Su, Guannan; Zhou, Chunjiang; Wang, Yao; Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1,Chongqing Eye Inst, Chongqing Branch Natl Clin Res Ctr Ocular Dis, Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Yang, Peizeng] Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China"

通信作者:"Yang, PZ (通讯作者),Chongqing Med Univ, Affiliated Hosp 1,Chongqing Eye Inst, Chongqing Branch Natl Clin Res Ctr Ocular Dis, Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China.; Yang, PZ (通讯作者),Chongqing Med Univ, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源:CLINICAL IMMUNOLOGY

ESI学科分类:IMMUNOLOGY

WOS号:WOS:000813025100002

JCR分区:Q1

影响因子:8.6

年份:2022

卷号:240

期号: 

开始页: 

结束页: 

文献类型:Article

关键词:CD4(+) T cell; Triglyceride; Behcet's disease; Experimental autoimmune uveitis

摘要:"Aberrant lipid metabolism plays a role in inflammation and progression of autoimmune diseases but the definite mechanism remains unclear. In this study we investigate lipidomic profiles in Behcet's disease (BD) and the role of triglyceride (TAG) in the pathogenesis of autoimmune uveitis. Lipidomics revealed a distinct lipid metabolite profile including increased TAG metabolites in plasma of active BD patients. TAG could stimulate the proliferation, IL-17 and IFN-gamma expression by CD4(+) T cells and Th1, Th17 cell differentiation in vitro, but did not influence neutrophils. A922500 inhibited the TAG generation, ameliorated the EAU severity, decreased Th17 frequency and IL-17 expression by CD4(+) T cells in vivo. The proteomocis analysis showed an up-regulation of apoptosis-related protein, Pik3r2, in CD4(+) T cells from A922500-treated mice. In conclusion, TAG can stimulate human CD4(+) T cells and the inhibition of its generation could significantly ameliorate EAU activity in association with down-regulated Th17 cell response."

基金机构:Natural Science Foundation Major International (Regional) Joint Research Project [81720108009]; National Natural Science Foundation Key Program [81930023]; Chongqing Outstanding Scientists Project [2019]; Chongqing Chief Medical Scientist Project [2018]; Chongqing Key Laboratory of Ophthalmology (CSTC) [2008CA5003]; Chongqing Science & Technology Platform and Base Construction Program [CSTC2021jscx-gksb-N0010]; Key Project of Chongqing Science and Technology Bureau [cstc2014pt-sy10002]

基金资助正文:"This study was supported by Natural Science Foundation Major International (Regional) Joint Research Project (81720108009), National Natural Science Foundation Key Program (81930023), Chongqing Outstanding Scientists Project (2019), the Chongqing Chief Medical Scientist Project (2018), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002) and Key Project of Chongqing Science and Technology Bureau (CSTC2021jscx-gksb-N0010)."