Polystyrene nanoparticles aggravate the adverse effects of di-(2-ethylhexyl) phthalate on different segments of intestine in mice

作者全名:"Yu, Ziying; Xia, Yinyin; Cheng, Shuqun; Mao, Lejiao; Luo, Shiyue; Tang, Shixin; Sun, Wei; Jiang, Xuejun; Zou, Zhen; Chen, Chengzhi; Qiu, Jingfu; Zhou, Lixiao"

作者地址:"[Yu, Ziying; Xia, Yinyin; Cheng, Shuqun; Sun, Wei; Chen, Chengzhi] Chongqing Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Chongqing 400016, Peoples R China; [Mao, Lejiao; Zou, Zhen] Chongqing Med Univ, Inst Life Sci, Mol Biol Lab Resp Dis, Chongqing 400016, Peoples R China; [Mao, Lejiao; Jiang, Xuejun; Zou, Zhen; Chen, Chengzhi] Chongqing Med Univ, Res Ctr Environm & Human Hlth, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Luo, Shiyue; Tang, Shixin; Qiu, Jingfu; Zhou, Lixiao] Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Lab Technol, Chongqing 400016, Peoples R China; [Jiang, Xuejun] Chongqing Med Univ, Ctr Expt Teaching Publ Hlth, Expt Teaching & Management Ctr, Chongqing 400016, Peoples R China; [Chen, Chengzhi] 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者:"Qiu, JF; Zhou, LX (通讯作者),Chongqing Med Univ, Sch Publ Hlth, Dept Hlth Lab Technol, Chongqing 400016, Peoples R China.; Chen, CZ (通讯作者),1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源:CHEMOSPHERE

ESI学科分类:ENVIRONMENT/ECOLOGY

WOS号:WOS:000822550600003

JCR分区:Q1

影响因子:8.8

年份:2022

卷号:305

期号: 

开始页: 

结束页: 

文献类型:Article

关键词:Polystyrene nanoparticles; Di-(2-ethylhexyl) phthalate; Intestinal damage; Combined toxicity; Gut microbiota

摘要:"Emerging evidence indicates that nanoplastics (NPs) can transport organic pollutants such as di-(2-ethylhexyl) phthalate (DEHP) into organisms and induce adverse health effects. Nevertheless, the toxic effects of NPs combined with DEHP on mammalian intestine are still unclear. In this study, the C57BL6J mice were exposed to polystyrene nanoparticles (PSNPs), DEHP or them both for 30 days to determine their effects on different segments of intestine and the gut microbiota. As a result, DEHP alone or co-exposure to DEHP and PSNPs induced histological damages in all intestinal parts, mainly manifested as the decreased villus lengths, increased crypt depths in the duodenum, jejunum and ileum and decreased villus counts accompanied with decreased epithelial area in the colon. Moreover, decreased mucus coverage, down-regulated Muc2 expression levels as well as the broken tight junctions were observed in intestinal epithelium of mice, particularly obvious in the co-treatment groups. In general, as manifested by greater alterations in most of the parameters mentioned above, simultaneously exposed to PSNPs and DEHP seemed to induce enhanced toxic effects on intestine of mouse when compared with DEHP alone. Furthermore, the altered community composition of gut microbiota might at least partially contribute to these abnormalities. Overall, our results highlight the aggravated toxicity on different segments of intestine in mammalians due to co-exposure of PSNPs and DEHP, and these findings will provide valuable insights into the health risk of NPs and plastic additives."

基金机构:"Postdoctoral Research Project of Chongqing Municipality [XmT2020379]; Chongqing Postdoctoral Science Foundation of China [cstc2021jcyj-bshX0139]; Chongqing Talent Project [CQYC2020058650, CQYC2021058941]"

基金资助正文:"Acknowledgments This work was financially supported by the Postdoctoral Research Project of Chongqing Municipality (No. XmT2020379) , Chongqing Postdoctoral Science Foundation of China (No. cstc2021jcyj-bshX0139) and Chongqing Talent Project (CQYC2020058650; CQYC2021058941) . Z.Z. and C.C. were both the Young talent of Bayu scholar."