Ferrocene-based multifunctional nanoparticles for combined chemo/ chemodynamic/photothermal therapy

作者全名："Yang, Jiahui; Yang, Liu; Li, Qin; Zhang, Liangke"

作者地址："[Yang, Jiahui; Yang, Liu; Li, Qin; Zhang, Liangke] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China"

通信作者："Zhang, LK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing Key Lab Biochem & Mol Pharmacol, Chongqing 400016, Peoples R China."

来源：JOURNAL OF COLLOID AND INTERFACE SCIENCE

ESI学科分类：CHEMISTRY

WOS号：WOS:000829364200011

JCR分区：Q1

影响因子：9.9

年份：2022

卷号：626

期号：　

开始页：719

结束页：728

文献类型：Article

关键词：Photothermal therapy; Chemodynamic therapy; Ferrocene; Tumor

摘要："Ferrocene and its derivatives have great potential for biomedical applications, but few related studies have been reported. In this study, copper ions and ferrocene derivatives were used for the first time to construct the ferrocene-based nanoparticles (Cu-Fc) with a hydrated particle size of approximately 220 nm. Their good photothermal conversion properties were verified in vitro and in vivo for the first time, indicating that they could be used as a novel photothermal agent for tumor treatment. In addition, the nanoparticles exhibited efficient Fenton effect under weakly acidic conditions, indicating that they can generate hydroxyl radicals (.OH) to kill tumors in the weakly acidic environment of the tumor -specific microenvironment. More importantly, the nanoparticles can deplete glutathione (GSH), thus fur-ther enhancing Fenton effect-mediated chemodynamic therapy (CDT). Multifunctional ferrocene-based nanoparticles (DOX@Cu-Fc) were obtained after loading the chemotherapeutic drug doxorubicin hydrochloride (DOX). The results of in vitro and in vivo experiments showed that DOX@Cu-Fc could enhance tumor treatment by the combination of chemo/CDT/photothermal therapy (PTT).(c) 2022 Elsevier Inc. All rights reserved."

基金机构：Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0795]; National Natural Science Foundation of China [81871368]

基金资助正文：Acknowledgements This work was supported by the Natural Science Foundation Project of CQ CSTC (cstc2018jcyjAX0795) and the National Natural Science Foundation of China (81871368) .