The 90% minimum effective volume and concentration of ropivacaine for ultrasound-guided median nerve block in children aged 1-3 years: A biased-coin design up-and-down sequential allocation trial

作者全名："Gao, Wen; Chen, YuJiao; Wang, Weiping; Li, Shangyingying; Bai, Lin; Wang, Hong; Li, Dazhen; Shi, Yuan; Xu, Hongzhen; Tu, Shengfen; Yang, Fei"

作者地址："[Gao, Wen; Wang, Weiping; Li, Shangyingying; Bai, Lin; Wang, Hong; Li, Dazhen; Shi, Yuan; Xu, Hongzhen; Tu, Shengfen; Yang, Fei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ, Dept Anesthesiol,Childrens Hosp,Key Lab Child De, Chongqing, Peoples R China; [Gao, Wen; Wang, Weiping; Tu, Shengfen] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Chen, YuJiao] North Sichuan Med Coll, Affiliated Hosp, Nanchong, Sichuan, Peoples R China"

通信作者："Tu, SF; Yang, F (通讯作者)，Chongqing Med Univ, Dept Anesthesiol, S Hosp, 136 Second Zhongshan Rd, Chongqing 400014, Peoples R China."

来源：JOURNAL OF CLINICAL ANESTHESIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000837859000001

JCR分区：Q1

影响因子：6.7

年份：2022

卷号：79

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：MEV90; MEC90; Pediatrics; Median nerve block; Ultrasound-guided

摘要："Background: Median nerve block can provide excellent analgesia during open surgery for trigger thumb in children. However, no data on the 90% minimum effective volume (MEV90) and concentration (MEC90) of ropivacaine for ultrasound-guided median nerve block in pediatric patients have been reported. Design: A prospective two-phase study with an up-and-down sequential allocation trial using a biased coin design. Patients: Children aged 1-3 years are experiencing open surgery for trigger thumb. Intervention: This study has 2 parts, one for MEV90 and subsequently studied MEC90 from the former part of the study. The MEV90 and MEC90 of ropivacaine for each subsequent patient were determined by the response of the previous patient, with the biased coin design up-and-down sequential allocation trial. The interval of -volume or concentration was -0.1 ml or 0.01%, respectively. Measurements: The MEV90 and MEC90 of ropivacaine for ultrasound-guided median nerve block in pediatric patients, were then used to estimate the 99% minimum effective volume (MEV99) and concentration (MEC99). The patient's general condition, postoperative pain, and adverse events. Main results: A total of one hundred and eighteen children were enrolled for the study, and 56 and 62 patients were enrolled for the MEV90 and MEC90 studies, respectively. The MEV90 of 0.2% ropivacaine was 1.44 ml (95% CI 1.043 ml, 1.466 ml), and the MEC90 of 1.5 ml ropivacaine was 0.195% (95% CI 0.159%, 0.197%). There were no adverse events that occurred. Conclusion: For ultrasound-guided median nerve block in children aged 1-3 years old with trigger finger undergoing open surgery, the MEV90 of 0.2% ropivacaine is 1.44 ml (95% CI 1.043 ml, 1.466 ml), and the MEC90 of 1.5 ml of ropivacaine is 0.195% (95% CI 0.159%, 0.197%)."

基金机构：National Key Clinical Program [(2013) 544]; Natural Science Foundation of Chongqing [cstc2012jjA10036]; National Natural Science Foundation of China [31200853]

基金资助正文：This work was supported by the National Key Clinical Program [grant numbers (2013) 544]; Natural Science Foundation of Chongqing [grant numbers cstc2012jjA10036] and the National Natural Science Foundation of China [grant numbers 31200853].