Article Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis

作者全名:"Lu, Xiaoxue; Xu, Qiaolin; Tong, Yanan; Zhang, Zhujun; Dun, Guodong; Feng, Yuyang; Tang, Jie; Han, Dan; Mao, Yilan; Deng, Ling; He, Xiaoyi; Li, Qian; Xiang, Yang; Wang, FengChao; Zeng, Dongzhu; Tang, Bin; Mao, Xuhu"

作者地址:"[Lu, Xiaoxue; Tong, Yanan; Dun, Guodong; Feng, Yuyang; Han, Dan; Deng, Ling; He, Xiaoyi; Li, Qian; Xiang, Yang; Mao, Xuhu] Third Mil Med Univ, Coll Pharm, Dept Clin Microbiol & Immunol, Army Med Univ, Chongqing 400038, Peoples R China; [Lu, Xiaoxue; Tong, Yanan; Dun, Guodong; Feng, Yuyang; Han, Dan; Deng, Ling; He, Xiaoyi; Li, Qian; Xiang, Yang; Mao, Xuhu] Third Mil Med Univ, Lab Med Sci, Army Med Univ, Chongqing 400038, Peoples R China; [Xu, Qiaolin; Tang, Jie; Zeng, Dongzhu; Tang, Bin] Chongqing Med Univ, Dept Gen Surg, Affiliated Hosp 3, Chongqing 401120, Peoples R China; [Zhang, Zhujun] Third Mil Med Univ, Southwest Hosp, Dept Hosp Infect Control, Army Med Univ, Chongqing 400038, Peoples R China; [Mao, Yilan] Chongqing Med Univ, Nursing Coll, Class 2021 Undergrad, Chongqing 400016, Peoples R China; [Wang, FengChao] Third Mil Med Univ, Coll Prevent Med, Inst Combined Injury, Army Med Univ,State Key Lab Trauma Burns & Combin, Chongqing 400038, Peoples R China"

通信作者:"Mao, XH (通讯作者),Third Mil Med Univ, Coll Pharm, Dept Clin Microbiol & Immunol, Army Med Univ, Chongqing 400038, Peoples R China.; Mao, XH (通讯作者),Third Mil Med Univ, Lab Med Sci, Army Med Univ, Chongqing 400038, Peoples R China.; Zeng, DZ; Tang, B (通讯作者),Chongqing Med Univ, Dept Gen Surg, Affiliated Hosp 3, Chongqing 401120, Peoples R China."

来源:CELL REPORTS

ESI学科分类:MOLECULAR BIOLOGY & GENETICS

WOS号:WOS:000838702000004

JCR分区:Q1

影响因子:8.8

年份:2022

卷号:40

期号:3

开始页: 

结束页: 

文献类型:Article

关键词: 

摘要:"Both Fusobacterium nucleatum (F. nucleatum) and long non-coding RNA (lncRNA) EVADR are associated with colorectal cancer (CRC), but their relationship with CRC metastasis and the mechanisms by which EVADR promotes CRC metastasis are poorly understood. Here, we report that F. nucleatum promotes colo-rectal cancer cell metastasis to the liver and lung and that it can be detected in CRC-metastasis colonization in mouse models. Furthermore, F. nucleatum upregulates the expression of EVADR, which can increase the metastatic ability of CRC cells in vivo and in vitro. Mechanistically, elevated EVADR serves as a modular scaf-fold for the Y-box binding protein 1 (YBX1) to directly enhance the translation of epithelial-mesenchymal tran-sition (EMT)-related factors, such as Snail, Slug, and Zeb1. These findings suggest that EVADR induced by F. nucleatum promotes colorectal cancer metastasis through YBX1-dependent translation. The EVADR-YBX1 axis may be useful for the prevention and treatment of patients with F. nucleatum-associated CRC metastasis."

基金机构:"National Natural Science Foundation of China [81501796]; Natural Science Foundation of Chongqing [cstc2017jcyjAX0205, cstc2020jcyj-msxmX0220]; Science and Technology project of Yubei District of Chongqing [2020-35, 2021-37]; Project of School Management in Army Medical University [31024629]; Scientific Research Incubation project, The Third Affiliated Hospital of Chongqing Medical University [KY20079]"

基金资助正文:"The authors would like to thank the patients with CRC who donated their spec-imen and time to this study. We are grateful to Drs. Shiming Yang and Huang Wu for helpful suggestions. We are grateful for the help provided by Dr. Kebin Zhang of Small Animal Imaging Technology. This work was supported by grants from the National Natural Science Foundation of China (no. 81501796) , Natural Science Foundation of Chongqing (nos. cstc2017jcyjAX0205 and cstc2020jcyj-msxmX0220) , the Science and Technology project of Yubei District of Chongqing (nos. 2020-35 and 2021-37) , and Project of School Management in Army Medical University (no. 31024629) . In addition, this work was supported by the grant no. KY20079 from the Scientific Research Incubation project, The Third Affiliated Hospital of Chongqing Medical University."