Metabolic risk factors of cognitive impairment in young women with major psychiatric disorder

作者全名："Zhuo, Chuanjun; Liu, Wei; Jiang, Ronghuan; Li, Ranli; Yu, Haiping; Chen, Guangdong; Shan, Jianmin; Zhu, Jingjing; Cai, Ziyao; Lin, Chongguang; Cheng, Langlang; Xu, Yong; Liu, Sha; Luo, Qinghua; Jin, Shili; Liu, Chuanxin; Chen, Jiayue; Wang, Lina; Yang, Lei; Zhang, Qiuyu; Li, Qianchen; Tian, Hongjun; Song, Xueqin; China multiple organs damagein the mental disorder CMODMD Group"

作者地址："[Zhuo, Chuanjun] Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China; [Zhuo, Chuanjun] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China; [Zhuo, Chuanjun; Song, Xueqin] Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China; [Zhuo, Chuanjun] Multiple Organs Damage Mental Disorder MODMD Ctr W, Wenzhou, Peoples R China; [Zhuo, Chuanjun; Wang, Lina] Tianjin Anding Hosp, Dept Psychiat, Tianjin, Peoples R China; [Liu, Wei] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, Harbin, Peoples R China; [Jiang, Ronghuan] Gen Hosp PLA, Dept Psychiat, Beijing, Peoples R China; [Li, Ranli] Tianjin Med Univ, Tianjin Anding Hosp, Key Lab Psychiat Neuroimaging Genet & Cor morbid, Tianjin Mental Hlth Ctr, Tianjin, Peoples R China; [Yu, Haiping; Chen, Guangdong; Shan, Jianmin; Zhu, Jingjing; Cai, Ziyao; Lin, Chongguang; Cheng, Langlang] Wenzhou Seventh Peoples Hosp, Inpatient Dept, Wenzhou, Peoples R China; [Xu, Yong; Liu, Sha] Shanxi Med Univ, Hosp 1, Dept Psychiat, Clin Med Coll 1, Taiyuan, Peoples R China; [Luo, Qinghua] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China; [Jin, Shili; Liu, Chuanxin] Shandong Daizhuang Hosp, Inpatient Dept, Jining, Peoples R China; [Chen, Jiayue] Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China; [Yang, Lei] Yanan Fifth Hosp, Dept Psychiat, Yanan, Peoples R China; [Zhang, Qiuyu] Tianjin Anning Hosp, Dept Psychiat, Tianjin, Peoples R China; [Li, Qianchen] Hebei Fifth Peoples Hosp, Dept Psychiat, Shijiazhuang, Peoples R China; [Tian, Hongjun] Tianjin Med Univ, Nankai Univ,Affiliated Tianjin Ctr Hosp 4, Key Lab Multiple Organ Damage Patients Mental Diso, Tianjin Fourth Ctr Hosp, Tianjin, Peoples R China; [Song, Xueqin] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China"

通信作者："Zhuo, CJ (通讯作者)，Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China.; Zhuo, CJ (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China.; Zhuo, CJ; Song, XQ (通讯作者)，Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China.; Zhuo, CJ (通讯作者)，Multiple Organs Damage Mental Disorder MODMD Ctr W, Wenzhou, Peoples R China.; Zhuo, CJ (通讯作者)，Tianjin Anding Hosp, Dept Psychiat, Tianjin, Peoples R China.; Luo, QH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.; Tian, HJ (通讯作者)，Tianjin Med Univ, Nankai Univ,Affiliated Tianjin Ctr Hosp 4, Key Lab Multiple Organ Damage Patients Mental Diso, Tianjin Fourth Ctr Hosp, Tianjin, Peoples R China.; Song, XQ (通讯作者)，Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000840666100001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：major psychiatric disorder; metabolic syndrome; HbA1c; cognitive impairment; risk factors

摘要："BackgroundCognitive performance improves clinical outcomes of patients with major psychiatric disorder (MPD), but is impaired by hyperglycemia. Psychotropic agents often induce metabolism syndrome (MetS). The identification of modifiable metabolic risk factors of cognitive impairment may enable targeted improvements of patient care. ObjectiveTo investigate the relationship between MetS and cognitive impairment in young women with MPD, and to explore risk factors. MethodsWe retrospectively studied women of 18-34 years of age receiving psychotropic medications for first-onset schizophrenia (SCH), bipolar disorder (BP), or major depressive disorder (MDD). Data were obtained at four time points: presentation but before psychotropic medication; 4-8 and 8-12 weeks of psychotropic therapy; and enrollment. MATRICS Consensus Cognitive Battery, (MCCB)-based Global Deficit Scores were used to assess cognitive impairment. Multiple logistic analysis was used to calculate risk factors. Multivariate models were used to investigate factors associated with cognitive impairment. ResultsWe evaluated 2,864 participants. Cognitive impairment was observed in 61.94% of study participants, and was most prevalent among patients with BP (69.38%). HbA1c within the 8-12 week-treatment interval was the most significant risk factor and highest in BP. Factors in SCH included pre-treatment waist circumference and elevated triglycerides during the 8-12 weeks treatment interval. Cumulative dosages of antipsychotics, antidepressants, and valproate were associated with cognitive impairment in all MPD subgroups, although lithium demonstrated a protect effect (all P < 0.001). ConclusionsCognitive impairment was associated with elevated HbA1c and cumulative medication dosages. Pre-treatment waist circumference and triglyceride level at 8-12 weeks were risk factors in SCH. Monitoring these indices may inform treatment revisions to improve clinical outcomes."

基金机构："National Natural Science Foundation of China [81871052, 82171503]; Key Projects of the Natural Science Foundation of Tianjin, China [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; Tianjin Science and Technology Bureau [15JCYBJC50800]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (81871052, 82171503 to CZ), the Key Projects of the Natural Science Foundation of Tianjin, China (17JCZDJC35700 to CZ), the Tianjin Health Bureau Foundation (2014KR02 to CZ), and the Tianjin Science and Technology Bureau (15JCYBJC50800 to HT)."