Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

作者全名："Xu, Dandan; Qiao, Deqian; Lei, Yunlong; Zhang, Chundong; Bu, Youquan; Zhang, Ying"

作者地址："[Xu, Dandan; Qiao, Deqian; Lei, Yunlong; Zhang, Chundong; Bu, Youquan; Zhang, Ying] Chongqing Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China; [Xu, Dandan; Qiao, Deqian; Lei, Yunlong; Zhang, Chundong; Bu, Youquan; Zhang, Ying] Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China"

通信作者："Bu, YQ; Zhang, Y (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China.; Bu, YQ; Zhang, Y (通讯作者)，Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China."

来源：CANCER LETTERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000848654800001

JCR分区：Q1

影响因子：9.7

年份：2022

卷号：546

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：tsRNA; Non-coding RNA; sncRNA; tRNA

摘要："tRNA-derived small RNAs (tsRNAs) represent a novel class of regulatory small non-coding RNAs (sncRNAs), produced by the specific cleavage of transfer RNAs (tRNAs). In recent years, pilot studies one after the other have uncovered the critical roles of tsRNAs in various fundamental biological processes as well as in the development of human diseases including cancer. Based on the newly updated hallmarks of cancer, we provide a comprehensive review regarding the dysregulation, functional implications and complicated molecular mech-anisms of tsRNAs in cancer. In addition, the potential technical challenges and future prospects in the fields of tsRNA research are discussed in this review."

基金机构："National Natural Science Foundation of China [82173243, 81872014, 81672301]; Scientific and Techno- logical Research Projects of Chongqing Education Commission [KJQN202100403]; Chongqing Municipal Science and Technology Commission [cstc2021jcyj-msxmX0186]"

基金资助正文："Funding This work was supported by the National Natural Science Foundation of China (No.82173243, 81872014, 81672301) , Scientific and Techno- logical Research Projects of Chongqing Education Commission (KJQN202100403) and Chongqing Municipal Science and Technology Commission (cstc2021jcyj-msxmX0186) ."