Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape
作者全名："Luo, Xing; Zeng, Xiaoqiang; Gong, Li; Ye, Yan; Sun, Cun; Chen, Ting; Zhang, Zelong; Tao, Yikun; Zeng, Hao; Zou, Quanming; Yang, Yun; Li, Jieping; Sun, Hongwu"
作者地址："[Luo, Xing; Zeng, Xiaoqiang; Ye, Yan; Sun, Cun; Chen, Ting; Zhang, Zelong; Tao, Yikun; Zeng, Hao; Zou, Quanming; Yang, Yun; Sun, Hongwu] Third Mil Med Univ, Coll Pharm, Dept MicroBiol & Biochemical Pharm, Natl Engn Res Centre Immunol Prod, Chongqing, Peoples R China; [Gong, Li] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 3, Chongqing, Peoples R China; [Li, Jieping] Chongqing Univ, Dept Hematol Oncol, Canc Hosp, Chongqing, Peoples R China; [Li, Jieping] Changsha Cent Hosp, Dept Hematol, Changsha, Peoples R China"
通信作者："Li, JP (通讯作者)，Chongqing Univ, Dept Hematol Oncol, Canc Hosp, Chongqing, Peoples R China.; Yang, Y; Sun, HW (通讯作者)，Third Mil Med Univ, Dept Microbiol & Biochem Pharm, Coll Pharm, Natl Engn Res Ctr Immunol Prod, Chongqing 400038, Peoples R China."
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
关键词：Mycobacterium tuberculosis; DNA vaccine; drug delivery; immune response; nanomaterials
摘要："Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently, effective nanomaterial-based delivery systems (including nanoparticles, nanogold, nanoliposomes, virus-like particles, and virus carriers) have been developed for DNA vaccines to control TB. This review highlights the historical development of various nanomaterial-based delivery systems for TB DNA vaccines, along with the emerging technologies. Nanomaterial-based vaccine delivery systems could enhance the efficacy of TB vaccination; therefore, this summary could guide nanomaterial selection for optimal and safe vaccine delivery, facilitating the design and development of highly effective TB vaccines."
基金机构："Natural Science Foundation of Hunan Province [2019JJ40321]; Scientific Research Project of Hunan Provincial Health Commission ; National Natural Science Foundation Program of China [32000651, 31670938, 32070924]; Natural Science Foundation Project Program of Chongqing [2022jcyjA1312, 2019jcyjA-msxmx0159, 2014jcyjA0107]"
基金资助正文："This research was supported by the Natural Science Foundation of Hunan Province (No. 2019JJ40321), Scientific Research Project of Hunan Provincial Health Commission (No. 20201933), National Natural Science Foundation Program of China (Nos. 32000651, 31670938, and 32070924), and Natural Science Foundation Project Program of Chongqing (Nos. 2022jcyjA1312, 2019jcyjA-msxmx0159 and 2014jcyjA0107). We thank LetPub (www.letpub.com) for linguistic assistance during the preparation of this manuscript."