Dual-Emission ZAISe/ZnS quantum dots for Multi-level Bio-Imaging: Foam cells and atherosclerotic plaque imaging
作者全名："Yu, Qinghua; Li, Jia; Zhang, Xianming; Yang, Shiyu; Zhou, Ping; Xia, Jiashan; Deng, Tao; Yu, Chao"
作者地址："[Yu, Qinghua; Zhang, Xianming; Yang, Shiyu; Zhou, Ping; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Yu, Qinghua; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 400016, Peoples R China; [Zhang, Xianming; Zhou, Ping; Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Li, Jia] Chongqing Med Univ, Dept Pharm, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Li, Jia] Chongqing Hlth Ctr Women & Children, Dept Pharm, Chongqing 401147, Peoples R China; [Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China"
通信作者："Tao, D; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China."
来源：JOURNAL OF COLLOID AND INTERFACE SCIENCE
关键词：Atherosclerosis plaque; dual-emission QDs; Bovine serum albumin; Macrophage-derived micro-vesicle; Bioimaging
摘要："In vitro or in vivo fluorescence imaging based on quantum dots (QDs) has shown promise for the nonin-vasive diagnosis of atherosclerosis. However, simultaneous in vitro and in vivo imaging remains challeng-ing due to the limitation of the current synthesis method of dual-emission QDs (dual-emitting hybrid QDs, and broad-spectrum emitting QDs). Herein, we fabricate a dual-emission (visible region and near -infrared region emission) QDs (ZAISe/ZnS) via the ""bottom to up"" method of a quaternary inorganic com-pound for the foam cells and atherosclerosis plaque imaging simultaneously without the intricate size modulation and the strict optical filter requirements. The oil-soluble ZAISe/ZnS is further encapsulated with bovine serum albumin (BSA) to realize phase transfer and ultimately possess the inflammation -targeting properties via biomimetic treatment with MMV (macrophage-derived micro-vesicle). The results first indicate that the as-constructed ZAISe/ZnS@BSA@MMV could accurately locate the foam cells and conduct long-term imaging of the atherosclerotic plaque, which provides a new strategy for the early and noninvasive diagnosis of atherosclerosis. Published by Elsevier Inc."
基金机构：China Postdoctoral Science Foundation [2019 M653356]; Chongqing Postdoctoral Science Foundation [cstc2019jcyjbshX0060]; Introduction Teachers Foundation of Chongqing Medical University [YXY2018BSH1]; Program for Youth Innovation in Future Medicine [W0090]
基金资助正文："This work was financially supported by the China Postdoctoral Science Foundation (2019 M653356) , Chongqing Postdoctoral Science Foundation (cstc2019jcyjbshX0060) , the Introduction Teachers Foundation of Chongqing Medical University (YXY2018BSH1) , and Program for Youth Innovation in Future Medicine (W0090) , Chongqing Medical University."