"Ultra-processed food consumption and the risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial"
作者全名："Zhong, Guo-Chao; Zhu, Qian; Cai, Dong; Hu, Jie-Jun; Dai, Xin; Gong, Jian-Ping; Sun, Wei-Ping"
作者地址："[Zhong, Guo-Chao; Cai, Dong; Hu, Jie-Jun; Dai, Xin; Gong, Jian-Ping] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhu, Qian] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Sun, Wei-Ping] Chongqing Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Chongqing, Peoples R China"
通信作者："Zhong, GC; Gong, JP; Sun, WP (通讯作者)，74 Linjiang Rd, Chongqing 400010, Peoples R China."
来源：INTERNATIONAL JOURNAL OF CANCER
文献类型：Article; Early Access
关键词：nutritional epidemiology; pancreatic cancer; ultra-processed foods
摘要："Whether ultra-processed food consumption is associated with the risk of pancreatic cancer has not been determined. We performed a prospective study to fill this gap. A population-based cohort of 98 265 American adults was identified from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Ultra-processed foods were defined by the NOVA classification. Cox regression was used to estimate hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was performed to identify the potential effect modifiers. During a mean follow-up of 8.86 years, 387 pancreatic cancer cases occurred. High consumption of ultra-processed foods was found to be associated with an increased risk of pancreatic cancer (fully adjusted HRquartile 4 vs 1:1.49; 95% confidence interval [CI]: 1.07-2.07; P-trend = .021) in a linear dose-response manner (P-nonlinearity = .075). Subgroup analysis further found that the positive association of ultra-processed food consumption with the risk of pancreatic cancer was more pronounced in subjects aged <65 years (HRquartile 4 vs 1:2.17; 95% CI: 1.14-4.15) than in those aged >= 65 years (HRquartile 4 vs 1:1.32; 95% CI: 0.88-1.94), though the interaction test failed to achieve the statistical significance (P-interaction = .061). These findings suggest that reducing ultra-processed food consumption may be beneficial in decreasing pancreatic cancer incidence."
基金机构：China Postdoctoral Science Foundation [2021M700638]; National Natural Science Foundation of China 
基金资助正文："China Postdoctoral Science Foundation, Grant/Award Number: 2021M700638; The National Natural Science Foundation of China, Grant/Award Number: 82203391"