Combination wound healing using polymer entangled porous nanoadhesive hybrids with robust ROS scavenging and angiogenesis properties

作者全名："Huang, Jixi; Wang, Shuai; Wang, Xiaoping; Zhu, Jing; Wang, Zhenqiang; Zhang, Ximu; Cai, Kaiyong; Zhang, Jixi"

作者地址："[Huang, Jixi; Wang, Shuai; Zhu, Jing; Wang, Zhenqiang; Cai, Kaiyong; Zhang, Jixi] Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, 174 Shazheng Rd, Chongqing 400044, Peoples R China; [Wang, Xiaoping; Zhang, Ximu] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401174, Peoples R China"

通信作者："Zhang, JX (通讯作者)，Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, 174 Shazheng Rd, Chongqing 400044, Peoples R China.; Zhang, XM (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401174, Peoples R China."

来源：ACTA BIOMATERIALIA

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000870054200004

JCR分区：Q1

影响因子：9.7

年份：2022

卷号：152

期号：　

开始页：171

结束页：185

文献类型：Article

关键词：Porous nanoadhesive; ROS scavenging; Interparticle cohesion; Polymer entanglement; Wound closure

摘要："Nanoadhesives can achieve tight wound closure by connecting biomacromolecules from both sides. How-ever, previously developed adhesive systems suffered from suboptimal wound healing efficiency due to the lack of interparticle cohesion, sufficient reactive oxygen species (ROS)-scavenging sites, and angiogen-esis consideration. Herein, we developed a polymer entangled porous nanoadhesive system to address the above challenge by synergy of three functional components. Firstly, hybrid mesoporous silica nanoparti-cles with highly integrated polydopamine (MS-PDA) were prepared by templated synthesis. The entan-gling between PVA polymer and MS-PDA contributed to much stronger cohesion between nanoparticles, which led to 75% larger adhesion strength. As confirmed by in vitro and in vivo evaluations, the highly exposed catechol groups boosted the scavenging activity of ROS (1.8-4.1 fold enhancement as compared with nonporous counterpart). Consequently, more macrophages exhibited anti-inflammatory phenotype, leading to 2-2.6 fold lower pro-inflammatory cytokine levels. Moreover, the sustained release of bioac-tive SiO4 4 - by the disintegration of nanoparticles contributed to similar to 3-fold higher expression of VEGF and enhanced new blood vessel formation, as well as better wound repair. This platform can provide a new paradigm for developing multifunctional nanoadhesive systems in treating skin wounds."

基金机构："National Natural Science Foundation of China (NSFC) [22175027, 21734002]; Natural Science Foundation of Chongqing [cstc2021jcyjcxttX0002, cstc2021jcyj-msxmX0178]; Program for Youth Innovation in Future Medicine from Chongqing Medical University [W0075]; Fundamental Research Funds for the Central Universities [2022CDJXY-026]; Graduate Scientific Research, and Innovation Foundation of Chongqing, China [CYB21071]"

基金资助正文："This work was supported in part by the National Natural Science Foundation of China (NSFC, Grant nos. 22175027, 21734002), the Natural Science Foundation of Chongqing (cstc2021jcyjcxttX0002, cstc2021jcyj-msxmX0178), and Program for Youth Innovation in Future Medicine from Chongqing Medical University (W0075), Project No. 2022CDJXY-026 supported by the Fundamental Research Funds for the Central Universities, Project supported by Graduate Scientific Research, and Innovation Foundation of Chongqing, China (Grant no. CYB21071). We would like to thank the Analytical and Testing Center of Chongqing University for the assistance during particle structure characterizations."