Effect of transcutaneous auricular vagus nerve stimulation on post-stroke dysphagia

作者全名："Wang, Ying; He, Yingxi; Jiang, Linlin; Chen, Xiaoxu; Zou, Fengjiao; Yin, Ying; Li, Jiani; Li, Changqing; Zhang, Guifang; Ma, Jingxi; Niu, Lingchuan"

作者地址："[Wang, Ying; He, Yingxi; Jiang, Linlin; Chen, Xiaoxu; Zou, Fengjiao; Yin, Ying; Niu, Lingchuan] Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Li, Jiani; Li, Changqing; Zhang, Guifang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Ma, Jingxi] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, Chongqing 401147, Peoples R China"

通信作者："Niu, LC (通讯作者)，Chongqing Med Univ, Dept Rehabil, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：JOURNAL OF NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000878454300004

JCR分区：Q1

影响因子：6

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Transcutaneous auricular electrical vagus nerve stimulation; Stroke; Dysphagia; Swallowing function

摘要："Background and purpose It has been proved that electrical vagus nerve stimulation can promote the recovery of motor function after stroke. There were no trials on the use of transcutaneous auricular electrical vagus nerve stimulation (ta-VNS) in patients with dysphagia after acute stroke. Our aim was to confirm whether ta-VNS can promote the recovery of swallowing function in these acute stroke patients with dysphagia. Methods We conducted a sham-controlled, double-blinded, parallel pilot study in 40 acute stroke patients randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training. The intensity of ta-VNS treatment was adjusted according to the patient's tolerance, 30 min each time, twice a day, five times a week, with a total course of 3 weeks. In the sham group, the parameters were the same except energy output. Swallowing function was assessed with Modified Mann assessment of swallowing ability (MASA), functional communication measure swallowing test (FCM), and the Rosenbek leakage/aspiration scale (RAS) according to swallowing video fluoroscopic (SVF) before the intervention (baseline, T0), immediately after the intervention (T1) and 4 weeks after the intervention (T2). Results After treatment, ta-VNS group statistically and clinically had larger change of MASA, FCM, and RAS scores compared with control group (P < 0.05) and this improvement continued at least 4 weeks after the end of treatment. There were no serious adverse events occurred during the whole intervention. Conclusion The transcutaneous auricular electrical vagus nerve stimulation is effective as a novel and noninvasive treatment strategy for patients with dysphagia after acute stroke."

基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2019MSXM017]; General project of Chongqing Natural Science Foundation (Chongqing Science and Technology Bureau) [cstc2021jcyj-msxmX0232]

基金资助正文："The experiment was funded by Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (No. 2019MSXM017), General project of Chongqing Natural Science Foundation (General project of Chongqing Natural Science Foundation (Chongqing Science and Technology Bureau) (cstc2021jcyj-msxmX0232)."