Banoxantrone Coordinated Metal-Organic Framework for Photoacoustic Imaging-Guided High Intensity Focused Ultrasound Therapy
作者全名："Sun, Tingyu; Li, Jingnan; Zeng, Chao; Luo, Chengyan; Luo, Xirui; Zhang, Huijie; Li, Huanan"
作者地址："[Sun, Tingyu; Li, Jingnan; Zeng, Chao; Luo, Chengyan; Luo, Xirui; Zhang, Huijie; Li, Huanan] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China"
通信作者："Li, HN (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China."
来源：ADVANCED HEALTHCARE MATERIALS
文献类型：Article; Early Access
关键词：HIFU; hypoxia-activated; nanomedicines; photoacoustic imaging; tumor theranostics
摘要："Photoacoustic (PA) imaging with high spatial resolution has great potential as desired monitoring means in the high-intensity focused ultrasound (HIFU) surgery of tumor. However, its penetration depth in the tissue is insufficient for achieving accurate intraoperative navigation, leading to residual tumor tissue. Nanomedicine provides a new opportunity for PA imaging to guide HIFU surgery. Studies have found that the hypoxic heterogeneity of tumor is effectively reversed by HIFU. Herein, a specific metal-organic framework nanosystem, constructed by coordination of banoxantrone (AQ4N) and Mn2+, is designed based on HIFU to reverse the hypoxic heterogeneity of tumors. It could provide exogenous light-absorbing substances, thus improving the penetrability of PA imaging signal through the deep tissue and achieving clearer PA imaging for guiding HIFU surgery. In turn, AQ4N, in the hypoxic homogenous environment of the tumor provided by HIFU, is activated sequentially to specifically treat the residual hypoxic tumor cells. This combination treatment manifests higher tumor suppressors activation and lower expression of genes related to tumor progression. This strategy addresses the dissatisfaction with PA imaging-guided HIFU therapy and is promising for translation into a clinical combination regimen."
基金机构："National Natural Science Foundation of China [82001851, 82272024]"
基金资助正文：The authors acknowledge the financial support from the National Natural Science Foundation of China (grant nos. 82001851 and 82272024).