Homomesoporous Metal-Organic Framework for High- Performance Electrochromatographic Separation
作者全名："Gui, Yuanqi; Zeng, Jing; Wang, Lujun; Long, Wenwen; You, Mingyue; Tao, Xueping; Huang, Yike; Xia, Zhining; Rao, Li; Fu, Qifeng"
作者地址："[Gui, Yuanqi; Zeng, Jing; Wang, Lujun; Long, Wenwen; You, Mingyue; Tao, Xueping; Xia, Zhining; Fu, Qifeng] Southwest Med Univ, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China; [Xia, Zhining; Rao, Li] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Huang, Yike] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"
通信作者："Fu, QF (通讯作者)，Southwest Med Univ, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China.; Rao, L (通讯作者)，Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China.; Huang, YK (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."
文献类型：Article; Early Access
摘要："Metal-organic frameworks (MOFs) have exhibited tremendous potential in the area of separation science. However, most of the developed MOF-based stationary phases contained only microporous structures and suffer from limited separation performance. Herein, homomesoporous MOFs with excellent mass transfer capability and strong thermodynamic interactions are first explored as the novel stationary phase for high-performance capillary electrochromatographic separations. As a proof of concept, noninterpenetrated mesoMOF-1 with uniform mesopore sizes (22.5 x 26.1 angstrom) and good stability was facilely grown on the inner surface of capillaries and applied as a homomesoporous MOF coating-based stationary phase for high-efficiency electrochromatographic separation. Seven types of analytes with different molecular dimensions were all baseline separated on a mesoMOF-1 coated column with high theoretical plate numbers and excellent repeatability, exhibiting significantly improved separation selectivity and column efficiency in comparison to a microporous HKUST-1 coated column. The maximum column efficiencies of the mesoMOF-1 coated column for substituted benzenes and halobenzenes reached up to 1.4 x 105 plates/m, and its mass loadability was also much higher than that of the HKUST-1 coated column. In addition, based on the analysis of adsorption kinetics and chromatographic retention behaviors, the interaction and retention mechanisms of different molecular-weight analytes on mesoMOF-1 coated stationary phases were systematically explored and disclosed in detail. These results indicate that the homomesoporous MOF-based stationary phase can effectively balance the kinetic diffusion (mass transfer capability) and thermodynamic interactions (the strength of adsorption interaction), having great potential for high-performance chromatographic separation."
基金机构：National Natural Science Foundation of China; Sichuan Science and Technology Program; Research Fund of Southwest Medical University; ; ; ; [2021JDRC0104]; [2021ZKMS039]
基金资助正文："? ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (Grant No. 21804113, 22074126 and 21974015) , the Sichuan Science and Technology Program (Grant No. 2021JDRC0104) , and the Research Fund of Southwest Medical University (Grant No. 2021ZKMS039) ."