Injectable catechin-based supramolecular hydrogel for highly efficient application in HPV-associated OSCC

作者全名："Lei, Shangxue; Hu, Xiaopei; Song, Shaojuan; Zhang, Yuting; Zhao, Hang; Xu, Xiaoping; Dan, Hongxia"

作者地址："[Lei, Shangxue; Hu, Xiaopei; Song, Shaojuan; Zhang, Yuting; Zhao, Hang; Xu, Xiaoping; Dan, Hongxia] Sichuan Univ, Chinese Acad Med Sci, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Sichuan, Peoples R China; [Lei, Shangxue] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China"

通信作者："Xu, XP; Dan, HX (通讯作者)，Sichuan Univ, Chinese Acad Med Sci, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Sichuan, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000900007000001

JCR分区：Q2

影响因子：7

年份：2023

卷号：11

期号：6

开始页：1191

结束页：1202

文献类型：Article

关键词：　

摘要："Catechins are a group of natural polyphenols extracted from green tea. Notably, they have been proven to have excellent anti-HPV and anti-tumour properties and to be effective against some HPV-related diseases, showing great potential in the treatment of HPV-associated oral squamous cell carcinoma (HPV+ OSCC). However, the poor bioavailability, short half-lives, and stability issues of catechins hamper their clinical application. To overcome these shortcomings of catechins, we innovatively synthesised an injectable supramolecular hydrogel, namely catechin-phenylenebisboronic acid-isoguanosine (CPBisoG), with catechin (one of the simplest catechins) and isoguanosine (isoG), another natural product with self-assembly ability, via dynamic phenylborate diester bonds. The biodegradation and sustained-release time of the CPBisoG hydrogel in mice lasted up to 72 h. This supramolecular hydrogel not only functioned as a good local drug delivery platform with good stability, injectability, self-healing properties, biocompatibility, biodegradability, but also exhibited therapeutic effects toward HPV+ OSCC in vitro and in vivo. And interestingly, it also showed selective inhibition against HPV+ OSCC cells. In all, these results demonstrate that this catechin-based hydrogel could sustainedly and highly effectively treat HPV+ OSCC topically, which could also provide a promising strategy for the management of other HPV-associated diseases in the future."

基金机构："National Natural Science Foundation of China [81922020, 82071125, U19A2005]; Department of Science and Technology of Sichuan Province [2021-YJ-0021, 2020YFS0044]; Research Funding for Talents Developing, West China Hospital of Stomatology, Sichuan University [RCDWJS2020-4]; West China Hospital of Stomatology, Sichuan University [LCYJ2019-11]; Multidisciplinary Research Program of West China Hospital of Stomatology, Sichuan University [RD-03-202109]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2020-I2M-CT-A-023, 2019-I2M-5-004]"

基金资助正文："The authors gratefully acknowledge the support for this work from the National Natural Science Foundation of China (81922020, 82071125, U19A2005), the Department of Science and Technology of Sichuan Province (2021-YJ-0021, 2020YFS0044), the Research Funding for Talents Developing, West China Hospital of Stomatology, Sichuan University (RCDWJS2020-4), the Research and Develop Program, West China Hospital of Stomatology, Sichuan University (LCYJ2019-11), the Multidisciplinary Research Program of West China Hospital of Stomatology, Sichuan University (RD-03-202109), and the CAMS Innovation Fund for Medical Sciences (CIFMS, 2020-I2M-C&T-A-023, 2019-I2M-5-004)."