A pH/GSH dual responsive nanoparticle with relaxivity amplification for magnetic resonance imaging and suppression of tumors and metastases
作者全名："Zhu, Xianglong; Xiong, Hehe; Yang, Pei; Wang, Songwei; Zhou, Qiuju; Zhang, Pengbo; Zhao, Zhenghuan; Shi, Saige"
作者地址："[Zhu, Xianglong; Yang, Pei; Zhang, Pengbo; Shi, Saige] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China; [Xiong, Hehe] Xiamen Univ, Sch Publ Hlth, Xiamen 361102, Peoples R China; [Wang, Songwei; Zhou, Qiuju] Xinyang Normal Univ, Anal Testing Ctr, Xinyang 464000, Peoples R China; [Zhao, Zhenghuan] Chongqing Med Univ, Coll Basic Med, Chongqing 400716, Peoples R China"
通信作者："Zhu, XL; Shi, SG (通讯作者)，Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China.; Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med, Chongqing 400716, Peoples R China."
摘要："Engineered magnetic nanoparticles combining diagnosis and therapy functions into one entity hold great potential to rejuvenate cancer treatment; however, they are still constrained by the ""always on"" signals and unsatisfactory therapeutic effect. Here, we report an intelligent theranostic probe based on Mn3O4 tetragonal bipyramids (MnTBs), which simultaneously respond to H+ and glutathione (GSH) with high sensitivity and quickly decompose to release Mn2+ in mild acidic and reductive intracellular environments. Mn2+ binds to the surrounding proteins to achieve a remarkable relaxivity amplification and selectively brighten the tumors. Particularly, this MR signal improvement is also effective in the detection of millimeter-sized liver metastases, with an ultrahigh contrast of 316%. Moreover, Mn2+ would trigger chemodynamic therapy (CDT) by exerting the Fenton-like activity to generate OH from H2O2. Subsequently, a significant tumor suppression effect can be achieved by the GSH depletion-enhanced CDT. Besides, MnTBs manifest efficient urinary and hepatic excretions with biodegradability and minimal systemic toxicity. A pH/GSH dual responsive nanoprobe that integrates tumor diagnostic and therapeutic activities was developed to provide a new paradigm for precise diagnosis and treatment of tumors and metastases."
基金机构："National Natural Science Foundation of China ; Foundation of Science and Technology Department of Henan Province [182102310104, 182102310105]; Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent) [CQYC201905077]; Creative Research Group of CQ University [CXQT21017]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0105]; Doctoral Scientist Research Foundation of XXMU [XYBSKYZZ202208]"
基金资助正文："This work was supported by the National Natural Science Foundation of China (21705138), the Foundation of Science and Technology Department of Henan Province (182102310104, 182102310105), the Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent CQYC201905077), the Creative Research Group of CQ University (CXQT21017), the Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0105), and the Doctoral Scientist Research Foundation of XXMU (XYBSKYZZ202208)."