Sonosensitive Phase-Changeable Nanoparticle Mediated Enhanced Chemotherapy in Prostate Cancer by Low-Intensity Focused Ultrasound
作者全名："Dai, Junyong; Wu, Yunfang; Chen, Ziqun; Xiao, Linkang; Zhang, Weili; Cao, Yang"
作者地址："[Dai, Junyong; Wu, Yunfang; Chen, Ziqun; Xiao, Linkang; Zhang, Weili; Cao, Yang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Urol Surg,Chongqing Key Lab Ultrasound MolIma, Chongqing 400010, Peoples R China; [Dai, Junyong] Chongqing Univ, Canc Hosp, Chongqing 400044, Peoples R China; [Wu, Yunfang] Chongqing Wanzhou Dist Maternal & Child Hlth Hosp, Chongqing 404197, Peoples R China; [Xiao, Linkang] Chongqing Gen Hosp, Chongqing 400013, Peoples R China"
通信作者："Zhang, WL; Cao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Dept Urol Surg,Chongqing Key Lab Ultrasound MolIma, Chongqing 400010, Peoples R China."
来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
关键词：prostate cancer; phase-changeable nanoparticles; chemotherapy; low-intensity focused ultrasound
摘要："Prostate cancer (PCa) is one of the most common cancer types. Early detection of PC offers the best chance of successful treatment. A noninvasive, image-guided therapy mediated by targeted nanoparticles (NPs) has the potential to improve the efficacy and safety of cancer therapies. Herein, we report a sonosensitive nanoparticle modified with anti-PSMA (prostate-specific membrane antigen) antibodies to activate target prostate tumors. These nanoparticles (PFP@IR780@PTX@liposome NPs) were co-loaded with the chemotherapeutic agent docetaxel and the sonosensitizer IR780, as well as phase-changeable perfluorocarbon (PFC) liquids. The liquid-gas phase change could be induced by low-intensity focused ultrasound (LIFU) in vitro. We found that the PFP@IR780@PTX@liposome NPs can specifically accumulate in prostate tumors after LIFU irradiation, as monitored by ultrasound and photoacoustic imaging. Meanwhile, docetaxel was controllably released from the nanoparticles to achieve enhanced chemotherapeutic therapy in vivo. These sonosensitive phase-changeable NPs can visually treat prostate cancers effectively and have a clinical potential."
基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0120]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2023MSXM085]; Senior Medical Talents Program of Chongqing for Young and Middle-aged
基金资助正文："This work was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0120), Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau, 2023MSXM085) and Senior Medical Talents Program of Chongqing for Young and Middle-aged."