Neutrophil extracellular traps and complications of liver transplantation

作者全名："Liu, Yanyao; Yan, Ping; Bin, Yue; Qin, Xiaoyan; Wu, Zhongjun"

作者地址："[Liu, Yanyao; Yan, Ping; Bin, Yue; Wu, Zhongjun] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Qin, Xiaoyan] Childrens Hosp Chongqing Med Univ, Dept Gen Surg & Trauma Surg, Key Lab Child Dev & Disorders, Minist Educ, Chongqing, Peoples R China; [Qin, Xiaoyan] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China"

通信作者："Wu, ZJ (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000910561200001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：neutrophil extracellular traps; liver transplantation; ischemia-reperfusion injury; acute rejection; thrombosis; hepatocellular carcinoma recurrence; therapeutic targets

摘要："Many end-stage liver disease etiologies are attributed to robust inflammatory cell recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil phagocytosis, oxidative burst, and degranulation. It has also been suggested that neutrophils may release neutrophil extracellular traps (NETs) to kill pathogens. It has been proven that neutrophil infiltration within the liver contributes to an inflammatory microenvironment and immune cell activation. Growing evidence implies that NETs are involved in the progression of numerous complications of liver transplantation, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. NETs are discussed in this comprehensive review, focusing on their effects on liver transplantation complications. Furthermore, we discuss NETs as potential targets for liver transplantation therapy."

基金机构：National Natural Science Foundation of China; [81873592]; [82170666]

基金资助正文：Funding This work was supported by the National Natural Science Foundation of China (No. 81873592 and No.82170666).