Pathogenesis and histological changes of nephropathy associated with COVID-19

作者全名："Lin, Lirong; Deng, Junhui; Tan, Wei; Li, Jie; Wu, Zhifeng; Zheng, Luquan; Yang, Jurong"

作者地址："[Lin, Lirong; Deng, Junhui; Tan, Wei; Wu, Zhifeng; Zheng, Luquan; Yang, Jurong] Chongqing Med Univ, Affiliated Hosp 3, Gener Hosp, Dept Nephrol, Chongqing 401120, Peoples R China; [Li, Jie] Yongchuan Peoples Hosp Chongqing, Dept Nephrol, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Gener Hosp, Dept Nephrol, Chongqing 401120, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000911465200231

JCR分区：Q1

影响因子：12.7

年份：2023

卷号：95

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：COVID-19; histological; kidney injury; SARS-CoV-2

摘要："Coronavirus disease 2019 (COVID-19) can cause damage to multiple organ, not only to the lungs, but also to the kidneys. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute and chronic kidney disease through direct viral infection, indirect injury, and vaccination-related injury. Like lung injury, kidney injury is also an important aspect affecting the severity and prognosis of SARS-CoV-2. This article summarizes the pathogenesis, pathological manifestations, and clinical features of SARS-CoV-2 direct or indirect renal injury. Including direct injury, indirect injury, special comorbidities (receiving kidney transplantation and chronic kidney disease), and vaccine-related renal injury, and exploring the possible therapeutic effect of anti-SARS-CoV-2 therapy on renal injury. The purpose is to provide reference for understanding COVID-19-related renal injury, guiding clinical and pathological diagnosis and treatment, and evaluating prognosis."

基金机构："National Natural Science Foundation of China [82270723, 81770682]; Chongqing Talent Program Project [cstc2021ycjhbgzxm0090]; Special project for technological innovation and application development of Chongqing [cstc2019jscxmsxmX0166]"

基金资助正文："The National Natural Science Foundation of China, Grant/Award Numbers: 82270723, 81770682; The Chongqing Talent Program Project, Grant/Award Number: cstc2021ycjhbgzxm0090; The Special project for technological innovation and application development of Chongqing, Grant/Award Number: cstc2019jscxmsxmX0166"