Mechanism of ferroptosis in traditional chinese medicine for clinical treatment: A review
作者全名："Liu, Jiajiao; Jiang, Guanyin; He, Pengfei; Du, Xing; Hu, Zhenming; Li, Fuxiang"
作者地址："[Liu, Jiajiao; Li, Fuxiang] Southwest Med Univ, Sch Clin Med, Luzhou, Peoples R China; [Jiang, Guanyin; Du, Xing; Hu, Zhenming] Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China; [Jiang, Guanyin; Du, Xing; Hu, Zhenming] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [He, Pengfei] Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China"
通信作者："Li, FX (通讯作者)，Southwest Med Univ, Sch Clin Med, Luzhou, Peoples R China.; Du, X; Hu, ZM (通讯作者)，Chongqing Med Univ, Orthoped Lab, Chongqing, Peoples R China.; Du, X; Hu, ZM (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China."
来源：FRONTIERS IN PHARMACOLOGY
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
关键词：traditional Chinese medicine; ferroptosis; function mechanism; clinical application; clinical disease
摘要："Ferroptosis is an iron-dependent regulation of cell death driven by lipid peroxidation, which is intracellularly dependent on iron and independent of other metals, and morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. Ferroptosis is closely related to physiological and pathological processes, such as development, aging, and immunity, and it plays an important role in a variety of diseases. In many departments, traditional Chinese medicine plays an increasingly important role in their clinical treatment. In recent years, an increasing number of studies have been conducted on the mechanism of ferroptosis in traditional Chinese medicine. However, the role of ferroptosis in the clinical treatment of traditional Chinese medicine requires further exploration. This article mainly introduces the application of ferroptosis in studies of the mechanism of traditional Chinese medicine to help clinicians understand the current status of traditional Chinese medicine therapy for the treatment of ferroptosis-related diseases."
基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0972]; Sichuan Provincial Cadre Health Research Project [2022-1303]; Military Medical Research Project of the General Hospital of the Western Theater Command Funding [2019LH05]
基金资助正文："Funding This study was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0972), Sichuan Provincial Cadre Health Research Project (2022-1303) and Military Medical Research Project of the General Hospital of the Western Theater Command Funding (2019LH05)."