"Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges"
作者全名："Jia, Wenhui; Zhou, Li; Li, Lei; Zhou, Ping; Shen, Zhisen"
作者地址："[Jia, Wenhui] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy,West China Sch, Chengdu 610041, Peoples R China; [Jia, Wenhui] Sichuan Univ, West China Hosp, Canc Ctr, Collaborat Innovat Ctr Biotherapy,West China Sch, Chengdu 610041, Peoples R China; [Zhou, Li] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing 400016, Peoples R China; [Li, Lei] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu 611137, Peoples R China; [Zhou, Ping] Hainan Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Haikou 571199, Peoples R China; [Shen, Zhisen] Ningbo Univ, Affiliated Lihuili Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Ningbo 315211, Peoples R China"
通信作者："Zhou, P (通讯作者)，Hainan Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Haikou 571199, Peoples R China.; Shen, ZS (通讯作者)，Ningbo Univ, Affiliated Lihuili Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Ningbo 315211, Peoples R China."
关键词：polyphenolic compounds; nanosystem; drug delivery; cancer treatment
摘要："Polyphenols and their derivates, a kind of natural product distributed in herb plants, vegetables, and fruits, are the most abundant antioxidants in the human diet and have been found to display cancer-preventative effects in several epidemiological studies. The scientific community has also validated the anti-cancer bioactivities and low toxicities of polyphenolic compounds, including flavones, tannins, phenolic acids, and anthocyanins, through in vitro and in vivo studies. However, the low stability, weak targeting ability, poor solubility, and low bioavailability of pure polyphenolic agents have significantly impaired their treatment efficacy. Nowadays, nano-based technology has been applied to surmount these restrictions and maximize the treatment efficacy of polyphenols. In this review, we summarize the advantages and related mechanisms of polyphenols in cancer treatment. Moreover, aiming at the poor solubility and low bioavailability of pure polyphenols in vivo, the advantages of nano-based delivery systems and recent research developments are highlighted. Herein, particular emphasis is mainly placed on the most widely used nanomaterials in the delivery of natural products, including liposomes, micelles, and nanogels. Finally, we present an overview and the challenges of future implementations of nano-based delivery systems of polyphenolic compounds in the cancer therapeutic field."
基金机构：National Natural Science Foundation of China ; Ningbo Clinical Research Center for Otolaryngology Head and Neck Disease [2022L005]; Ningbo Medical and Health Brand Discipline [PPXK2018-02]; Ningbo "Technology Innovation 2025" Major Special Project [2020Z097]
基金资助正文："This work was funded by the National Natural Science Foundation of China, grant number 8226100505, the Ningbo Clinical Research Center for Otolaryngology Head and Neck Disease, grant number 2022L005, and the Ningbo Medical and Health Brand Discipline, grant number PPXK2018-02, Ningbo ""Technology Innovation 2025"" Major Special Project, grant number 2020Z097."