Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer
作者全名："Lu, Weiyu; Xie, Biao; Tan, Guangqing; Dai, Wanying; Ren, Jingyi; Pervaz, Sadaf; Li, Kun; Li, Fangfang; Wang, Yingxiong; Wang, Meijiao"
作者地址："[Lu, Weiyu; Tan, Guangqing; Dai, Wanying; Ren, Jingyi; Li, Kun; Wang, Meijiao] Chongqing Med Univ, Sch Basic Med Sci, Dept Physiol, Chongqing, Peoples R China; [Xie, Biao] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Biostat, Chongqing, Peoples R China; [Pervaz, Sadaf; Li, Fangfang; Wang, Yingxiong; Wang, Meijiao] Chongqing Med Univ, Sch Publ Hlth & Management, Joint Int Res Lab Reprod & Dev, Minist Educ China, Chongqing, Peoples R China"
通信作者："Wang, MJ (通讯作者)，Chongqing Med Univ, Sch Basic Med Sci, Dept Physiol, Chongqing, Peoples R China.; Wang, MJ (通讯作者)，Chongqing Med Univ, Sch Publ Hlth & Management, Joint Int Res Lab Reprod & Dev, Minist Educ China, Chongqing, Peoples R China."
来源：FRONTIERS IN ENDOCRINOLOGY
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000924125800001
JCR分区：Q2
影响因子：5.2
年份：2023
卷号：14
期号：
开始页：
结束页：
文献类型：Article
关键词：ovarian cancer; elafin; immune infiltation; prognosis; CIBERSORT; nomogram; IHC analysis
摘要："BackgroundOvarian cancer (OC) is the most lethal gynecologic malignancy, yet the clinical results for OC patients are still variable. Therefore, we examined how elafin expression affects the patients' prognoses and immunotherapy responses in OC, which may facilitate treatment selection and improve prognosis. MethodsThe elafin mRNA expression profile was downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus. Elafin's prognostic potential and its relationship with clinical variables were investigated using Kaplan-Meier survival curves, time-dependent receiver operating characteristic curves as well as univariate and multivariate Cox regression models. As validation, protein expression in the tumor and adjacent tissues of OC patients was investigated by using immunohistochemistry (IHC). Comprehensive analyses were then conducted to explore the correlation between immune infiltration and elafin expression. ResultsA higher mRNA expression of elafin was associated with an unfavorable prognosis in TCGA cohort and was validated in GSE31245 and IHC. Moreover, elafin was indicated as an independent risk factor for OC. A significantly higher protein expression of elafin was detected in the adjacent tissues of OC patients with shorter overall survival (OS). The immune-related pathways were mainly enriched in the high-elafin-mRNA-expression group. However, the mRNA expression of elafin was favorably correlated with indicators of the immune filtration and immunotherapy response, which also proved better immunotherapy outcomes. ConclusionThe high elafin expression was associated with an unfavorable OS, while it also indicated better immunotherapy responses. Thus, the detection of elafin is beneficial to diagnosis and treatment selection."
基金机构："National Natural Science Foundation of China [82171624, 82204159]; Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0294]; Science and Technology Project of Chongqing Yuzhong District [20200103]; Scientific Research and Innovation Experiment Project of Chongqing Medical University [SRIEP202002, SRIEP202106]; Chongqing Postdoctoral Science Foundation [cstc2021jcyj-bsh0029]"
基金资助正文："This study was supported by grants from the National Natural Science Foundation of China (no. 82171624 and no. 82204159), the Chongqing Natural Science Foundation (no. cstc2020jcyj-msxmX0294), the Science and Technology Project of Chongqing Yuzhong District (no. 20200103), the Scientific Research and Innovation Experiment Project of Chongqing Medical University (no. SRIEP202002 and no. SRIEP202106), and the Chongqing Postdoctoral Science Foundation (no. cstc2021jcyj-bsh0029)."
