Effects of smoking on the severity and transmission of pulmonary tuberculosis: A hospital-based case control study

作者全名："Feng, Yanmei; Xu, Yue; Yang, Yuan; Yi, Guangzhao; Su, Huan; Chen, Hong; Guo, Rui; Jia, Jinwei; Wang, Pu"

作者地址："[Feng, Yanmei; Su, Huan; Chen, Hong; Wang, Pu] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China; [Xu, Yue] First Peoples Hosp, Dept Infect Dis, Chongqing Liang Jiang New Area, Chongqing, Peoples R China; [Yang, Yuan] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China; [Yi, Guangzhao] Chongqing Med Univ, Dept Hosp Infect Control, Affiliated Hosp 1, Chongqing, Peoples R China; [Guo, Rui] Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China; [Jia, Jinwei] Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Resp Med, Chongqing, Peoples R China"

通信作者："Wang, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing, Peoples R China.; Guo, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Chongqing, Peoples R China.; Jia, JW (通讯作者)，Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Dept Resp Med, Chongqing, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:000929328900001

JCR分区：Q1

影响因子：5.2

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：pulmonary tuberculosis; smoking; severity of the disease; positive tubercle bacilli; transmission

摘要："IntroductionThere is a high incidence of both smoking and tuberculosis (TB) in China. This study examined the risk factors for severe pulmonary TB (PTB) and positive tubercle bacilli in sputum. MethodsWe conducted a retrospective case-control study in a tertiary hospital from January 2017 to December 2018 (n = 917). The clinical and biological characteristics of patients were collected, and univariable and multivariable logistic regression analyses were performed to assess the factors associated with smoking in terms of the severity and transmission of PTB. ResultsPositive tubercle bacilli in sputum and severe PTB were much higher in smoking patients. Together with nutrition status, heavy smoking exhibited a 284% greater risk in severe PTB. Positive tubercle bacilli in sputum was significantly associated with hypoproteinemia and smoking regardless of the status, duration, and degree. ConclusionBecause cigarette smoking was strongly and inversely associated with hypoproteinemia, we conclude that smoking plays a critical role in the severity and transmission of PTB. Smoking cessation interventions should be employed to prevent severe PTB and decrease the transmission of PTB."

基金机构：Basic Research and Frontier Exploration Project of Chongqing Yuzhong District Science and Technology Committee [20180139]; Joint Science Project of Chongqing Science and Technology Committee-Health Bureau [2018MSXM006]; Medical Talents Program of Chongqing for Young and Middle-aged

基金资助正文："This study was funded by the Basic Research and Frontier Exploration Project of Chongqing Yuzhong District Science and Technology Committee (No: 20180139), the Joint Science Project of Chongqing Science and Technology Committee-Health Bureau (No: 2018MSXM006), and the Medical Talents Program of Chongqing for Young and Middle-aged."