Covalent organic framework-supported ultrasmall Rh nanoparticles as peroxidase mimics for colorimetric sensing of cysteine
作者全名："Zhang, Li; Zhang, Wendong; Nie, Yao; Wang, Yi; Zhang, Pu"
作者地址："[Zhang, Li; Zhang, Wendong; Nie, Yao; Wang, Yi] Chongqing Normal Univ, Coll Chem, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat,Minist Ed, Chongqing 401331, Peoples R China; [Zhang, Pu] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China"
通信作者："Wang, Y (通讯作者)，Chongqing Normal Univ, Coll Chem, Engn Res Ctr Biotechnol Act Subst, Chongqing Key Lab Green Synth & Applicat,Minist Ed, Chongqing 401331, Peoples R China.; Zhang, P (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China."
来源：JOURNAL OF COLLOID AND INTERFACE SCIENCE
关键词：COF-Rh complex shows excellent; Covalent organic frameworks; Rhodium; Nanozymes; Cysteine; Smartphone
摘要："Covalent organic frameworks (COFs), as a novel porous organic polymer with periodic and highly ordered structure, are ideal carrier matrix for metal nanoparticles due to high specific surface area, good stability, controllable pore size, and structural tunability. In this work, COFs are used as a carrier to in-situ grow ultrasmall rhodium nanoparticles (Rh NPs, -2.4 nm), which are uniformly distributed in the pores and on the surfaces of the COFs. The formed composite (COF-Rh) shows excellent peroxidase-mimetic activity benefiting from the good catalytic activity of ultrafine and highly dispersed Rh NPs as well as the high affinity of COFs to organic molecules (i.e., catalytic substrates). Cysteine (Cys) can inhibit the peroxidase-like activity of COF-Rh due to the interaction of-SH in Cys with Rh and the reduction of oxi-dized peroxidase substrate by Cys. By regulating the peroxidase-like activity of the system, a colorimetric method is successfully developed for Cys detection. Using smartphone as a readout, a portable strategy further proposed for rapid and visual sensing of Cys.(c) 2023 Elsevier Inc. All rights reserved."
基金机构：National Natural Science Foundation of China ; Chongqing Innovation Research Group Project [CXQT21015]; Natural Science Foundation of Chongqing [cstc2021ycjh-bgzxm0113]; Chongqing Eyas Project [CY210504]
基金资助正文："This work was supported by the National Natural Science Foundation of China (no. 21775014), Chongqing Innovation Research Group Project (no. CXQT21015) , Natural Science Foundation of Chongqing (cstc2021ycjh-bgzxm0113), and Chongqing Eyas Project (CY210504)."