Allomelanin-based biomimetic nanotherapeutics for orthotopic glioblastoma targeted photothermal immunotherapy

作者全名:"Sun, Maoyuan; Li, Yan; Zhang, Wenli; Gu, Xiang; Wen, Rong; Zhang, Ke; Mao, Jinning; Huang, Chengyao; Zhang, Xiong; Nie, Mao; Zhang, Zhiwen; Qi, Chao; Cai, Kaiyong; Liu, Guodong"

作者地址:"[Sun, Maoyuan; Wen, Rong; Liu, Guodong] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing 400016, Peoples R China; [Li, Yan; Gu, Xiang; Zhang, Ke; Huang, Chengyao; Qi, Chao; Cai, Kaiyong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Zhang, Wenli] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400016, Peoples R China; [Mao, Jinning] Chongqing Med Univ, Affiliated Hosp 2, Hlth management Ctr, Chongqing 400016, Peoples R China; [Zhang, Xiong] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing 400016, Peoples R China; [Nie, Mao] Chongqing Med Univ, Affiliated Hosp 2, Dept Orthoped, Chongqing 400016, Peoples R China; [Zhang, Zhiwen] Fudan Univ, Sch Pharm & Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China"

通信作者:"Liu, GD (通讯作者),Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing 400016, Peoples R China.; Qi, C; Cai, KY (通讯作者),Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China."

来源:ACTA BIOMATERIALIA

ESI学科分类:MATERIALS SCIENCE

WOS号:WOS:001031515100001

JCR分区:Q1

影响因子:9.4

年份:2023

卷号:166

期号: 

开始页:552

结束页:566

文献类型:Article

关键词:Glioblastoma; Allomelanin; Tumor immunotherapy; Immune checkpoint blockade; Photothermal therapy

摘要:"Immune checkpoint blockade (ICB) therapy has shown great potential in the treatment of malignant tumors, but its therapeutic effect on glioblastoma (GBM) is unsatisfactory because of the low immunogenicity and T cell infiltration, as well as the presence of blood-brain barrier (BBB) that blocks most of ICB agents to the GBM tissues. Herein, we developed a biomimetic nanoplatform of AMNP@CLP@CCM for GBM-targeted photothermal therapy (PTT) and ICB synergistic therapy by loading immune checkpoint inhibitor CLP002 into the allomelanin nanoparticles (AMNPs) and followed by coating cancer cell membranes (CCM). The resulting AMNP@CLP@CCM can successfully cross the BBB and deliver CLP002 to GBM tissues due to the homing effect of CCM. As a natural photothermal conversion agent, AMNPs are used for tumor PTT. The increased local temperature by PTT not only enhances BBB penetration but also upregulates the PD-L1 level on GBM cells. Importantly, PTT can effectively stimulate immunogenic cell death to induce tumor-associated antigen exposure and promote T lymphocyte infiltration, which can further amplify the antitumor immune responses of GBM cells to CLP002-mediated ICB therapy, resulting in significant growth inhibition of the orthotopic GBM. Therefore, AMNP@CLP@CCM has great potential for the treatment of orthotopic GBM by PTT and ICB synergistic therapy."

基金机构:"National Natural Science Foundation of China [51802202, 21807074, 81401500]; Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002, cstc2019jcyj-msxmX0231]; Chongqing Talents: Youth Top-notch Talent Project [cstc2022ycjh-bgzxm0167]; Kuan-ren Talents Program of the Second Affiliated Hospital of Chongqing Medical University, Chongqing Scientific and Health Joint Medical Research Project [2020GDRC021]; Chongqing Postgraduate Research Innovation Project [CYS 22347]"

基金资助正文:"This work was financially supported by the National Natural Science Foundation of China (51802202 , 21807074 , and 81401500) , the Natural Science Foundation of Chongqing (cstc2021jcyj-cxttX0002 and cstc2019jcyj-msxmX0231) , Chongqing Talents: Youth Top-notch Talent Project (cstc2022ycjh-bgzxm0167) , Kuan-ren Talents Program of the Second Affiliated Hospital of Chongqing Medical University, Chongqing Scientific and Health Joint Medical Research Project (2020GDRC021) , and Chongqing Postgraduate Research Innovation Project (CYS 22347) ."