Enhancing cell adhesive and antibacterial activities of glass-fibre-reinforced polyetherketoneketone through Mg and Ag PIII

作者全名:"Tan, Xin; Wang, Zhongyi; Yang, Xin; Yu, Ping; Sun, Manlin; Zhao, Yuwei; Yu, Haiyang"

作者地址:"[Tan, Xin; Wang, Zhongyi; Yang, Xin; Sun, Manlin; Zhao, Yuwei; Yu, Haiyang] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Peoples R China; [Tan, Xin] Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Wang, Zhongyi] Nanjing Med Univ, Affiliated Hosp Stomatol, Jiangsu Key Lab Oral Dis, Nanjing, Peoples R China; [Yu, Ping] Chengdu Second Peoples Hosp, Dept Stomatol, Chengdu, Peoples R China"

通信作者:"Yu, HY (通讯作者),Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Peoples R China."












关键词:glass-fibre-reinforced polyetherketoneketone; plasma immersion ion implantation; human gingival fibroblasts; antibacterial activity

摘要:"Glass-fibre-reinforced polyetherketoneketone (PEKK-GF) shows great potential for application as a dental implant restoration material; however, its surface bioinertness and poor antibacterial properties limit its integration with peri-implant soft tissue, which is critical in the long-term success of implant restoration. Herein, functional magnesium (Mg) and silver (Ag) ions were introduced into PEKK-GF by plasma immersion ion implantation (PIII). Surface characterization confirmed that the surface morphology of PEKK-GF was not visibly affected by PIII treatment. Further tests revealed that PIII changed the wettability and electrochemical environment of the PEKK-GF surface and enabled the release of Mg2+ and Ag+ modulated by Giavanni effect. In vitro experiments showed that Mg/Ag PIII-treated PEKK-GF promoted the proliferation and adhesion of human gingival fibroblasts and upregulated the expression of adhesion-related genes and proteins. In addition, the treated samples inhibited the metabolic viability and adhesion of Streptococcus mutans and Porphyromonas gingivalis on their surfaces, distorting bacterial morphology. Mg/Ag PIII surface treatment improved the soft tissue integration and antibacterial activities of PEKK-GF, which will further support and broaden its adoption in dentistry."

基金机构: [2020C017]; [2020ACA0]

基金资助正文:"Acknowledgements The authors would like to thank Qiang Wei (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University) for guidance in using scanning electron microscope (No. 2020C017) and 3D profilometer (No. 2020ACA0)."