Protein modification by short-chain fatty acid metabolites in sepsis: a comprehensive review
作者全名:"Zhang, Liang; Shi, Xinhui; Qiu, Hongmei; Liu, Sijia; Yang, Ting; Li, Xiaoli; Liu, Xin"
作者地址:"[Zhang, Liang; Shi, Xinhui; Qiu, Hongmei; Liu, Sijia; Yang, Ting; Li, Xiaoli] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China; [Zhang, Liang; Shi, Xinhui; Qiu, Hongmei; Liu, Sijia; Yang, Ting; Li, Xiaoli] Chongqing Key Lab Drug Metab, Chongqing, Peoples R China; [Zhang, Liang; Shi, Xinhui; Qiu, Hongmei; Liu, Sijia; Yang, Ting; Li, Xiaoli] Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing, Peoples R China; [Liu, Xin] Third Mil Med Univ, Southwest Hosp, Med Res Ctr, Chongqing, Peoples R China"
通信作者:"Li, XL (通讯作者),Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China.; Li, XL (通讯作者),Chongqing Key Lab Drug Metab, Chongqing, Peoples R China.; Li, XL (通讯作者),Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing, Peoples R China.; Liu, X (通讯作者),Third Mil Med Univ, Southwest Hosp, Med Res Ctr, Chongqing, Peoples R China."
来源:FRONTIERS IN IMMUNOLOGY
ESI学科分类:IMMUNOLOGY
WOS号:WOS:001085963400001
JCR分区:Q1
影响因子:5.7
年份:2023
卷号:14
期号:
开始页:
结束页:
文献类型:Review
关键词:sepsis; short-chain fatty acids (SCFAs); protein post-translational modifications (PTMs); immunity; inflammation
摘要:"Sepsis is a major life-threatening syndrome of organ dysfunction caused by a dysregulated host response due to infection. Dysregulated immunometabolism is fundamental to the onset of sepsis. Particularly, short-chain fatty acids (SCFAs) are gut microbes derived metabolites serving to drive the communication between gut microbes and the immune system, thereby exerting a profound influence on the pathophysiology of sepsis. Protein post-translational modifications (PTMs) have emerged as key players in shaping protein function, offering novel insights into the intricate connections between metabolism and phenotype regulation that characterize sepsis. Accumulating evidence from recent studies suggests that SCFAs can mediate various PTM-dependent mechanisms, modulating protein activity and influencing cellular signaling events in sepsis. This comprehensive review discusses the roles of SCFAs metabolism in sepsis associated inflammatory and immunosuppressive disorders while highlights recent advancements in SCFAs-mediated lysine acylation modifications, such as substrate supplement and enzyme regulation, which may provide new pharmacological targets for the treatment of sepsis."
基金机构:"This project is supported by grants from the National Natural Science Foundation of China (81873955 and 82172133) and Chongqing National Natural Science Program (csct2020jcyj-msxmX0223 and csct2022nscq-msx0214). [81873955, 82172133]; National Natural Science Foundation of China [csct2020jcyj-msxmX0223, csct2022nscq-msx0214]; Chongqing National Natural Science Program"
基金资助正文:This project is supported by grants from the National Natural Science Foundation of China (81873955 and 82172133) and Chongqing National Natural Science Program (csct2020jcyj-msxmX0223 and csct2022nscq-msx0214).