"Self-Adhesive, Biocompatible, Wearable Microfluidics with Erasable Liquid Metal Plasmonic Hotspots for Glucose Detection in Sweat"

作者全名："Yuan, Qingwei; Fang, Hui; Wu, Xiuru; Wu, Jialin; Luo, Xie; Peng, Ran; Xu, Shanshan; Yan, Sheng"

作者地址："[Yuan, Qingwei; Wu, Xiuru; Wu, Jialin; Xu, Shanshan; Yan, Sheng] Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Peoples R China; [Yuan, Qingwei; Fang, Hui; Wu, Xiuru; Wu, Jialin] Shenzhen Univ, Inst Microscale Optoelect, Nanophoton Res Ctr, Shenzhen 518060, Peoples R China; [Luo, Xie] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400016, Peoples R China; [Peng, Ran] Dalian Maritime Univ, Coll Marine Engn, Dalian 116026, Peoples R China; [Yan, Sheng] Shenzhen Univ, Coll Mechatron & Control Engn, Shenzhen 518060, Peoples R China"

通信作者："Yan, S (通讯作者)，Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Peoples R China.; Yan, S (通讯作者)，Shenzhen Univ, Coll Mechatron & Control Engn, Shenzhen 518060, Peoples R China."

来源：ACS APPLIED MATERIALS & INTERFACES

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001096876800001

JCR分区：Q1

影响因子：8.3

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：wearable microfluidics; liquid metal; erasableplasmonic hotspots; SERS; glucose detection

摘要："Sweat is a noninvasive metabolite that can provide clinically meaningful information about physical conditions without harming the body. Glucose, a vital component in sweat, is closely related to blood glucose levels, and changes in its concentration can reflect the health status of diabetics. We introduce a self-adhesive, wearable microfluidic chip with erasable liquid metal plasmonic hotspots for the precise detection of glucose concentration in sweat. The self-adhesive, wearable microfluidic chip is made from modified polydimethylsiloxane (PDMS) with enhanced stickiness, enabling conformal contact with the skin, and can collect, deliver, and store sweat. The plasmonic hotspots are located inside the microfluidic channel, are generated by synthesizing silver nanostructures on liquid metal, and can be removed in the alkaline solution. It indicates the erasable and reproducible nature of the plasmonic hotspots. The detection method is based on surface-enhanced Raman spectroscopy (SERS), which allows for accurate detection of the glucose concentration. To enhance the sensitive detection of glucose, the SERS substrate is modified by 4-mercaptophenylboronic acid to achieve the limit of detection of 1 ng/L glucose, which is much lower than the physiological conditions (7.2-25.2 mu g/L). The developed microfluidic chip is soft, stretchable, and nontoxic, bringing new possibilities to wearable sweat-sensing devices."

基金机构："Guangdong Basic and Applied Basic Research Foundation [2021A1515110277]; Top Young Talent of the Pearl River Talent Recruitment Program [2021QN02Y387]; National Natural Science Foundation of China [52305609, 12074268, 83122015]; Nature Science Foundation of Guangdong Province [2018B030311048]; Natural Science Foundation of Liaoning Province [2022-MS-156]"

基金资助正文："This work was supported by Guangdong Basic and Applied Basic Research Foundation (2021A1515110277), Top Young Talent of the Pearl River Talent Recruitment Program (2021QN02Y387), National Natural Science Foundation of China (52305609, 12074268, 83122015), the Nature Science Foundation of Guangdong Province (2018B030311048), and Natural Science Foundation of Liaoning Province (2022-MS-156)."