Gel-to-Solution Transition of Sulfhydryl Self-Assembled Peptide Hydrogels Undergoing Oxidative Modulation

作者全名："Hu, Mai; Liu, Zhengli; Shen, Zhiwei"

作者地址："[Hu, Mai; Shen, Zhiwei] Nanchang Univ, Natl Engn Res Ctr Bioengn Drugs & Technol, Inst Translat Med, Nanchang 330088, Peoples R China; [Liu, Zhengli] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 400044, Peoples R China; [Shen, Zhiwei] Chongqing Med Univ, Key Lab Diagnost Med Designated, Minist Educ, Chongqing 400014, Peoples R China; [Shen, Zhiwei] Zhongyuan Huiji Biotechnol Co Ltd, Chongqing 400039, Peoples R China"

通信作者："Shen, ZW (通讯作者)，Nanchang Univ, Natl Engn Res Ctr Bioengn Drugs & Technol, Inst Translat Med, Nanchang 330088, Peoples R China.; Shen, ZW (通讯作者)，Chongqing Med Univ, Key Lab Diagnost Med Designated, Minist Educ, Chongqing 400014, Peoples R China.; Shen, ZW (通讯作者)，Zhongyuan Huiji Biotechnol Co Ltd, Chongqing 400039, Peoples R China."

来源：ACS APPLIED BIO MATERIALS

ESI学科分类：　

WOS号：WOS:001127568700001

JCR分区：Q2

影响因子：4.6

年份：2023

卷号：6

期号：12

开始页：5836

结束页：5841

文献类型：Article

关键词：self-assembly peptide; hydrogel; disulfide; oxidation-reduction; Raman spectra

摘要："The design of self-assembling biomaterials needs to take into consideration the timing and location of the self-assembly process. In recent decades, the principal strategy has been to control the peptide self-assembly under specific conditions to enable its functional performance. However, few studies have explored the responsive elimination of functional self-assembled peptide hydrogels after their function has been performed. We designed peptide ECAFF (ECF-5), which under reductive conditions can self-assemble into a hydrogel. Upon exposure to oxidizing conditions, disulfide bonds form between the peptides, altering their molecular structure and impacting their self-assembly capability. As a result, the peptide hydrogels transition to a soluble state. This study investigates the utilization of oxidation to induce a gel-to-solution transition in peptide hydrogels and provides an explanation for their degradation following free radical treatment. Self-assembled peptide hydrogel materials can be designed from a fresh perspective by considering the degradation that takes place after functional execution."

基金机构："National Natural Science Foundation of China [11674344, 22201026]; National Natural Science Foundation of China [QYZDJ-SSW-SLH019]; Key Research Program of Frontier Sciences, CAS"

基金资助正文："This study was supported by the National Natural Science Foundation of China (nos. 11674344 and 22201026) and the Key Research Program of Frontier Sciences, CAS (grant no. QYZDJ-SSW-SLH019)."