Atypical plaque psoriasis: a clinicopathological study of 20 cases

作者全名："Luo, Si-Yu; Zhou, Kai-Yi; Wang, Qin-Xiao; Deng, Li-Jia; Fang, Sheng"

作者地址："[Luo, Si-Yu; Zhou, Kai-Yi; Wang, Qin-Xiao; Deng, Li-Jia; Fang, Sheng] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Fang, Sheng] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Fang, S (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF DERMATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001163559600001

JCR分区：Q1

影响因子：3.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："BackgroundPlaque psoriasis is relatively straightforward to identify. When diagnostic concerns arise in atypical cases, a biopsy is needed. It is widely accepted that the Munro microabscess and the spongiform pustule of Kogoj are diagnostic pathological features. However, the diagnostic dilemma is likely to arise in cases without these specific pathological changes and typical clinical features. This study aimed to investigate clinical and pathological clues in distinguishing atypical plaque psoriasis from its mimics.MethodsWe evaluated the clinicopathological features of 20 cases of atypical plaque psoriasis and 40 cases of psoriasis mimics as controls including pityriasis rosea (n = 10), pityriasis lichenoides chronica (n = 8), and subacute dermatitis (n = 22).ResultsA retrospective analysis of the clinicopathological characteristics of patients with atypical plaque psoriasis and controls was performed. Pathologically, there were significant differences between the two groups in the types of parakeratosis (P = 0.046), epidermal capture of extravasated erythrocytes (P = 0.011), focal basal liquefied degeneration (P = 0.017), types of inflammatory cells (P = 0.000), and depth of inflammation (P = 0.000). Clinically, we found the presence of scales and crusts was significantly different between the two groups.ConclusionThis study offers insight into the clinicopathological features of atypical plaque psoriasis. These differential diagnostic features, compared with its mimics, are proposed to assist the clinician in the diagnosis and treatment of atypical plaque psoriasis."

基金机构：　

基金资助正文：