Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999-2023)

作者全名："Wang, Xin; Wu, Jiangfan; Ye, Hongjiang; Zhao, Xiaofang; Zhu, Shenyin"

作者地址："[Wang, Xin; Zhu, Shenyin] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, 1,Youyi Rd, Chongqing 400016, Peoples R China; [Wu, Jiangfan; Zhao, Xiaofang] Chongqing Med Univ, Sch Pharm, Chongqing, Peoples R China; [Ye, Hongjiang] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing 400016, Peoples R China; [Zhao, Xiaofang] Qiandongnan Miao & Dong Autonomous Prefecture Peop, Kaili City 556000, Guizhou, Peoples R China"

通信作者："Zhu, SY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, 1,Youyi Rd, Chongqing 400016, Peoples R China."

来源：PHARMACEUTICAL RESEARCH

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001170521000001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：bibliometrics analysis; citespace; physiologically based pharmacokinetic modeling; visualization; VOsviewers

摘要："PurposeThe physiologically based pharmacokinetic (PBPK) modeling has received increasing attention owing to its excellent predictive abilities. However, there has been no bibliometric analysis about PBPK modeling. This research aimed to summarize the research development and hot points in PBPK model utilization overall through bibliometric analysis.MethodsWe searched for publications related to the PBPK modeling from 1999 to 2023 in the Web of Science Core Collection (WoSCC) database. The Microsoft Office Excel, CiteSpace and VOSviewers were used to perform the analyses.ResultsA total of 4,649 records from 1999 to 2023 were identified, and the largest number of publications focused in the period 2018-2023. The United States was the leading country, and the Environmental Protection Agency (EPA) was the leading institution. The journal Drug Metabolism and Disposition published and co-cited the most articles. Drug-drug interactions, special populations, and new drug development are the main topics in this research field.ConclusionWe first visualize the research landscape and hotspots of the PBPK modeling through bibliometric methods. Our study provides a better understanding for researchers, especially beginners about the dynamization of PBPK modeling and presents the relevant trend in the future."

基金机构："Graduate Research Innovation Projects of Chongqing Province(CN); Department of Pharmacy, the First Affiliated Hospital of Chongqing Medical University; School of Pharmacy, Chongqing Medical University"

基金资助正文："We are grateful to the Department of Pharmacy, the First Affiliated Hospital of Chongqing Medical University and the School of Pharmacy, Chongqing Medical University for supporting this study."