Genetic prediction of the causal relationship between schizophrenia and tumors: a Mendelian randomized study

作者全名："Zhou, Xintong; Liu, Qi; Liu, Shihan; Wang, Liquan; Sun, Zhongli; Sun, Changgang; Cui, Xiangning"

作者地址："[Zhou, Xintong; Liu, Qi; Sun, Zhongli] Shandong Univ Tradit Chinese Med, Coll Clin Med 1, Jinan, Peoples R China; [Liu, Shihan] Chongqing Med Univ, Affiliated Hosp 2, Dept Otorhinolaryngol, Chongqing, Peoples R China; [Wang, Liquan] Weifang Peoples Hosp, Dept Thyroid & Breast Surg, Weifang, Peoples R China; [Sun, Changgang] Weifang Med Univ, Coll Tradit Chinese Med, Weifang, Peoples R China; [Sun, Changgang] Weifang Tradit Chinese Hosp, Dept Oncol, Weifang, Peoples R China; [Cui, Xiangning] China Acad Chinese Med Sci, Dept Cardiovasc, Guanganmen Hosp, Beijing, Peoples R China"

通信作者："Sun, CG (通讯作者)，Weifang Med Univ, Coll Tradit Chinese Med, Weifang, Peoples R China.; Sun, CG (通讯作者)，Weifang Tradit Chinese Hosp, Dept Oncol, Weifang, Peoples R China.; Cui, XN (通讯作者)，China Acad Chinese Med Sci, Dept Cardiovasc, Guanganmen Hosp, Beijing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001174363900001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：schizophrenia; cancer; mendelian randomization; causality; GWAS

摘要："Background Patients with schizophrenia are at a higher risk of developing cancer. However, the causal relationship between schizophrenia and different tumor types remains unclear.Methods Using a two-sample, two-way Mendelian randomization method, we used publicly available genome-wide association analysis (GWAS) aggregate data to study the causal relationship between schizophrenia and different cancer risk factors. These tumors included lung adenocarcinoma, lung squamous cell carcinoma, small-cell lung cancer, gastric cancer, alcohol-related hepatocellular cancer, tumors involving the lungs, breast, thyroid gland, pancreas, prostate, ovaries and cervix, endometrium, colon and colorectum, and bladder. We used the inverse variance weighting (IVW) method to determine the causal relationship between schizophrenia and different tumor risk factors. In addition, we conducted a sensitivity test to evaluate the effectiveness of the causality.Results After adjusting for heterogeneity, evidence of a causal relationship between schizophrenia and lung cancer risk was observed (odds ratio [OR]=1.001, 95% confidence interval [CI], 1.000-1.001; P=0.0155). In the sensitivity analysis, the causal effect of schizophrenia on the risk of lung cancer was consistent in both direction and degree. However, no evidence of causality or reverse causality between schizophrenia and other tumors was found.Conclusion This study elucidated a causal relationship between the genetic predictors of schizophrenia and the risk of lung cancer, thereby providing a basis for the prevention, pathogenesis, and treatment of schizophrenia in patients with lung cancer."

基金机构：National Natural Science Foundation of China10.13039/501100001809

基金资助正文：Thanks to the editors and reviewers for their hard work and important comments.