摘要:
The hematological changes, temperature. pulse, respiration, body weight and clinical manifestations were observed one hour before and after blood-element-pheresis in 100 random--selected donors. On the basis of different blood elements taken, number of cycles performed, and types of solution (ACD or HES) used , variations in the different groups were studied. The study aimed at the evaluation of the effect on the donors from whom large amouut of luecocytes and platelets were collected with HM 30 processor. The operation of pheresis was done by puncturing two veins and infusing ACD-A or HES (MW 45 × 10
4) solution for 2-8 hours.
Among the parameters recorded most of them showed a tendency to decrease, the mean of the general reduction being 9-20.1% and that of platelet count, 15, 8-53.3%. These changes might be due to the collection of large amount of blood elements within a short period of time the infusion of large quantity of ACD and normal saline cau-sing dilution of the blood and the expansion of plasma following injection of HES. During the course of the procedure, transient numbness of the upper extremities occurred ih 6 donors, chills, palpitaiion, shortness of breath, sweating and pallor in 4, perioral tingling sensation in 7 and urinary incontinence in 1. No serious reactions occurred. Thus the application of H-M 30 for leucapheresis and plateletpheresis was satisfactory and acceptably safe. The donors tolerate fairly well 4-8 cycles for 2-8hours