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Childhood maltreatment and suicide risk: The mediating role of self-compassion, mentalization, depression

JOURNAL OF AFFECTIVE DISORDERS 2023年第1期341卷 52-61页

作者： Huang, Manxia Hou, Jinbo China Univ Geosci Inst Educ Dept Psychol 388 Lumo Rd Wuhan 430074 Hubei Peoples R China China Univ Geosci Student Mental Hlth Educ Ctr Wuhan Peoples R China

Background: Childhood maltreatment (CM) is a well-established risk factor for depression and increased suicide risk. This study aimed to investigate the distinctive mechanisms of individual types of CM on young adult suicide risk, by exploring the potential mediating role of mentalization, self-compassion, and ***: A total of 4873 adults completed a survey screening for experiences of CM, self-compassion, mentalization, depression, and suicide ***: The path analysis revealed significant direct effects of mentalization, self-compassion, and depression on suicide risk. Moreover, mentalization, self-compassion, and depression mediated the relationship between emotional abuse/neglect and suicide risk, whereas physical neglect contributed to suicide risk only through mentalization and depression. Furthermore, sexual abuse had a significant direct effect on suicide risk, whereas physical abuse did not show any direct or indirect effects. Limitations: The cross-sectional design of the study limits its ability to establish causality, and the risk of recall bias in reporting physical or sexual abuse cannot be ***: This study represents the first identification of disturbances in self-compassion, mentalization, and depression that mediate the relationship between various types of CM and suicide risk in young adults. Our findings suggest substantive differences in the impact of emotional CM compared to other forms of CM. Enhancing self-compassion and mentalization abilities could be valuable intervention strategies for individuals with a history of emotional CM. Addressing factors that hinder the recall of relevant subjective experiences of physical and sexual abuse is also critical.

关键词： Childhood maltreatment Mentalization depression Suicide Self-compassion

来源： SCIE

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Depressive, anxiety, and somatoform disorders in primary care:: Prevalence and recognition

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depression AND ANXIETY 2007年第3期24卷 185-195页

作者： Mergl, Roland Seidscheck, Isabel Allgaier, Antje-Kathrin Moeller, Hans-Juergen Hegerl, Ulrich Henkel, Verena Univ Munich Dept Psychiat D-80336 Munich Germany

Recent studies emphasize the negative impact of comorbidity on the course of depression. If undiagnosed, depression and comorbidity contribute to high medical utilization. We aimed to assess (1) prevalences of depression alone and with comorbidity (anxiety/somatoform disorders) in primary care, (2) coexistence of anxiety/somatoform disorders in depressive patients, and (3) diagnostic validity of two screeners regarding depression with versus without comorbidity. We examined 394 primary care outpatients using the Composite International Diagnostic Interview (CIDI), the General Health Questionnaire (GHQ-12), and the Well-Being Index (WHO-5). We conducted configurational frequency analyses to identify nonrandom configurations of the disorders and receiver operating characteristic (ROC)-analyses to assess diagnostic validity of the screeners. Point prevalence of any depressive disorder was 22.8%;with at least one comorbid disorder, 15%;and with two comorbid conditions, 6.1%, which significantly exceeded expected percentage (0.9%, P depression without comorbidity occurred significantly less often than expected by chance (P depression with [GHQ-12: area under the curve (AUC) = 0.86;RWO-5: AUC = 0.88] and without comorbidity (GHQ-12: AUC = 0.84;RWO-5: AUC = 0.86). It can be concluded that comorbidity between depression and anxiety/somatoform disorders in primary care may occur much more frequently than expected. These results confirm assumptions that the current division between depression and anxiety might be debatable. Validity of screeners tested in our study was not affected by comorbid conditions (e.g., anxiety or somatoform disorders). (C) 2006 Wiley-Liss, Inc.

关键词： depression anxiety disorders comorbidity primary health care screening

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Childhood adversity and combat as predictors of depression and post-traumatic stress in deployed troops

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE 2007年第2期33卷 77-82页

作者： Cabrera, Oscar A. Hoge, Charles W. Bliese, Paul D. Castro, Carl A. Messer, Stephen C. US Army Med Res Unit Europe Heidelberg Germany Walter Reed Army Inst Res Dept Mil Psychiat Silver Spring MD USA

Background: Previous studies have shown a relationship between childhood adversity and health outcomes in adulthood. The military represents a segment of the young working population that faces unique hazards that may be worsened by previous adverse life experiences. To date, no comprehensive studies of childhood adversity have been conducted with military samples that have included combat troops before and after a combat deployment. Methods: Surveys were administered in 2003 to 4529 male soldiers who had not deployed to Iraq, and in 2004 to a separate group of 2392 male soldiers 3 months after returning from Iraq. The main predictor was adverse childhood experiences, an aggregated construct representing incremental exposure to six types of traumatic childhood experiences. This construct correlated with depression and post-traumatic stress disorder rates, as well as symptom scores. For the post-Iraq sample, analyses were conducted to assess whether individuals with childhood trauma were affected differently by exposure to combat. Results: The likelihood of screening positive for depression and post-traumatic stress disorder was significantly higher for individuals reporting exposure to two or more categories of childhood adversity. Core analyses showed that adverse childhood experiences were a significant predictor of mental health symptoms, beyond the expected contribution of combat. Conclusions: This study confirms the high prevalence of adverse childhood experiences and the association of these experiences with key mental health outcomes. In addition, the results highlight the importance of considering pre-enlistment childhood traumatic experiences as well as the level of combat exposure in the treatment of military personnel returning from combat operations.

关键词： Adolescent Adult Age Factors Child Child Welfare depression Health Surveys 成年人年龄因素儿童儿童福利抑郁症卫生调查伊拉克普查军事医学 Adolescent depression Child Welfare Post-Traumatic Stress Iraq Health Surveys childhood Child Fighter combat exposure Military Personnel Age Factor Adults POSITIVE SCREENS

来源： SCIE ClinicalKey（临床精钥...

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Integrating tuberculosis and mental health services: global receptivity of national tuberculosis program directors

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

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INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 2019年第5期23卷 600-605页

作者： Sweetland, A. C. Galea, J. Shin, S. S. Driver, C. Dlodlo, R. A. Karpati, A. Wainberg, M. L. New York State Psychiat Inst & Hosp Columbia Vagelos Coll Phys & Surg Dept Psychiat New York NY 10032 USA Univ S Florida Coll Behav & Community Sci Sch Social Work Tampa FL USA Univ Calif Irvine Sue & Bill Gross Sch Nursing Irvine CA USA Vital Strategies New York NY USA Int Union TB & Lung Dis Bulawayo Zimbabwe

SETTING: A global survey of National Tuberculosis Program (NTP) directors. OBJECTIVES: To assess the perceived mental health needs of persons with tuberculosis (TB), current practices, and receptivity to integrating evidence-based mental and substance use treatment into national TB guidelines. DESIGN: Semi-structured survey of NTP directors from 26 countries of all income levels using a standardized questionnaire. RESULTS: Of the 26 countries, 21 were classified as high incidence and/or burden countries for TB, TB and human immunodeficiency virus coinfection, and/or drug-resistant TB. Two NTPs included routine screening for any mental disorder, four assessed alcohol or drug use, and five had standard protocols for the co-management of disorders. If effective and low-cost integrated care models were available, 17 NTP directors felt that it was highly likely, and five somewhat likely, that their NTPs would integrate mental health treatment into national TB guidelines and services. The main perceived barriers to service integration were limited capacity, not recognizing mental health as a problem, insufficient resources, and TB-related social stigma. CONCLUSIONS: NTPs currently do not address mental disorders as part of routine practice. Nevertheless, receptivity is high, which creates a ripe opportunity to integrate the management of TB and mental disorders into the policies and guidelines of NTPs worldwide.

关键词： depression anxiety psychosis substance use disorders patient-centered care

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Shared decision making for adults with severe mental illness: A concept analysis

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JAPAN JOURNAL OF NURSING SCIENCE 2020年第4期17卷 e12365-e12365页

作者： Aoki, Yumi St Lukes Int Univ Grad Sch Nursing Psychiat & Mental Hlth Nursing Tokyo Japan

Aim Shared decision making for adults with severe mental illness has increasingly attracted attention. However, this concept has not been comprehensively clarified. This review aimed to clarify a concept of shared decision making for adults with severe mental illness such as schizophrenia, depression, and bipolar disorder, and propose an adequate definition. Methods Rodgers' evolutionary concept analysis was used. MEDLINE, PsychINFO, and CINAHL were searched for articles written in English and published between 2010 and November 2019. The search terms were "psychiatr*" or "mental" or "schizophren*" or "depression" or "bipolar disorder", combined with "shared decision making". In total, 70 articles met the inclusion criteria. An inductive approach was used to identify themes and sub-themes related to shared decision making for adults with severe mental illness. Surrogate terms and a definition of the concept were also described. Results Four key attributes were identified: user-professional relationship, communication process, user-friendly visualization, and broader stakeholder approach. Communication process was the densest attribute, which consisted of five phases: goal sharing, information sharing, deliberation, mutual agreement, and follow-up. The antecedents as prominent predisposing factors were long-term complex illness, power imbalance, global trend, users' desire, concerns, and stigma. The consequences included decision-related outcomes, users' changes, professionals' changes, and enhanced relationship. Conclusions Shared decision making for adults with severe mental illness is a communication process, involving both user-friendly visualization techniques and broader stakeholders. The process may overcome traditional power imbalance and encourage changes among both users and professionals that could enhance the dyadic relationship.

关键词： bipolar disorder depression review schizophrenia shared decision making

来源： ebsco(ASP/aph) SCIE

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Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence

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PSYCHOPHARMACOLOGY 2004年第4期174卷 561-570页

作者： Heinz, A Goldman, D Gallinat, J Schumann, G Puls, L Charite Univ Med Berlin Dept Psychiat D-10117 Berlin Germany NIAAA NIH Rockville MD 20852 USA Cent Inst Mental Hlth Mannheim Dept Psychiat Mannheim Germany

Rationale: Alcohol dependence is characterized by the development of tolerance, withdrawal symptoms, and craving for alcohol. Chronic alcohol consumption causes neuroadaptive changes in the central dopaminergic and serotonergic system, which are partially reversible after detoxification. The severity and time-course of recovery of these neuroadaptive changes may depend on the genetic constitution of monoamine transporters and receptors and contribute to the relapse risk of alcoholics. Objectives: To assess the interaction between the genetic constitution and the in vivo availability of dopamine and serotonin transporters and receptors, chronic alcohol intake, alcohol craving and withdrawal. Methods: Review of brain imaging studies that assess the genotype and availability of dopamine and serotonin transporters in detoxified alcoholics and healthy control subjects. Results: Chronic alcohol intake induced neuroadaptive reductions in striatal dopamine transporter (DAT) availability, which were reversible during early abstinence. A polymorphism of the DAT gene (SLC6A3) was associated with the in vivo transporter availability and with the severity of alcohol withdrawal. Neurotoxic reductions in 5-HTT protein expression were limited to homozygous carriers of the long allele in the 5-HTT gene (SCL6A4) regulatory region and correlated with negative mood states. Conclusion: Genetic constitution interacts with the in vivo availability of central dopamine and serotonin transporters during alcohol detoxification and may affect the severity of alcohol withdrawal and clinical depression.

关键词： SPECT beta-CIT genetic constitution alcoholism withdrawal depression

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Using multiple methods to characterize the phenotype of individuals with a family history of major depressive disorder

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JOURNAL OF AFFECTIVE DISORDERS 2013年第2期150卷 474-480页

作者： Watters, Anna J. Gotlib, Ian H. Harris, Anthony W. F. Boyce, Philip M. Williams, Leanne M. Univ Sydney Sch Med Discipline Psychiat Westmead NSW 2145 Australia Stanford Univ Stanford Mood & Anxiety Disorders Lab Stanford CA 94305 USA

Background: Unaffected relatives (URs) of individuals with major depressive disorder (MDD) are biologically more vulnerable to depression. We compare healthy URs and controls at the level of phenotype (symptoms and functioning) and endophenotype (negative emotion bias), and further investigate the interrelation between these and the contribution of environmental early life stress. Methods: URs (n = 101), identified using Family History Screen interview methods and matched controls completed written and interview questions assessing symptoms of depression and anxiety, negative cognitive style, life functioning and early life stress. Biases in emotion processing were measured using a facial expression of emotion identification paradigm. Results: Compared to controls, URs reported higher levels of depression and anxiety, a stronger negative cognitive bias, and poorer functioning and lower satisfaction with life. URs were slower to correctly identify fear and sad facial expressions. A slower response time to identify sad faces was correlated with lower quality of life in the social domain. Early life stress (ELS) did not contribute significantly to any outcome. Limitations: The methodology relies on accurate reporting of participants own psychiatric history and that of their family members. The degree of vulnerability varies among URs. Conclusions: A family history of depression accounts for subtle differences in symptom levels and functioning without a necessary role of ELS. A negative emotion bias in processing emotion may be one vulnerability marker for MDD. Biological markers may affect functioning measures before symptoms at the level of experience. (C) 2013 Elsevier B.V. All rights reserved,

关键词： Biomarkers depression Family study First-degree relatives Facial expressions of emotion Brain research and integrative neuroscience network (BRAINnet) facial

来源： ebsco(ASP/aph) SCIE

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A Stacking-Based Ensemble Approach with Embeddings from Language Models for depression Detection from Social Media Text

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Journal of Data Analysis and Information Processing 2023年第4期11卷 420-453页

作者： Akwa Gaius Ronald Waweru Mwangi Antony Ngunyi Department of Mathematics Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI) Nairobi Kenya Department of Computing Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Department of Statistics and Actuarial Sciences Dedan Kimathi University of Technology Nairobi Kenya

depression is a major public health problem around the world and contributes significantly to poor health and poverty. The rate of the number of people being affected is very high compared to the rate of medical treatment of the disease. Thus, the disease often remains untreated and suffering continues. Machine learning has been widely used in many studies in detecting depressive individuals from their contents on online social networks. From the related reviews, it is apparent that the application of stacking for diagnosing depression has been minimal. The study implements stacking based on Extra Tree, Extreme Gradient Boosting, Light Gradient Boosting and Multi-layer perceptron and compares its performance to state of the art bagging and boosting ensemble learners. To better evaluate the effectiveness of the proposed stacking approach, three pretrain word embeddings techniques including: Word2vec, Global Vectors and Embeddings from language models were employed with two datasets. Also, a corrected resampled paired t-test was applied to test the significance of the stacked accuracy against the baseline accuracy. The experimental results shows that the stacking approach yields favourable results with a best accuracy of 99.54%.

关键词： Machine Learning Natural Language Processing depression

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Multiple traumatic brain injury and concussive symptoms among deployed military personnel

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BRAIN INJURY 2013年第12期27卷 1333-1337页

作者： Bryan, Craig J. Natl Ctr Vet Studies Salt Lake City UT 84112 USA

Objective: To identify if concussive symptoms occur with greater frequency among military personnel with multiple lifetime TBIs and if a history of TBI increases risk for subsequent TBI. Patients: One hundred and sixty-one military personnel referred to a TBI clinic for evaluation and treatment of suspected head injury at a military clinic in Iraq. Methods: Military patients completed standardized self-report measures of concussion, depression and post-traumatic stress symptoms;clinical interview;and physical examination. Group comparisons were made according to number of lifetime TBIs and logistic regression was utilized to determine the association of past TBIs on current TBI. Results: Patients with one or more previous TBIs were more likely to report concussion symptoms immediately following a recent injury and during the evaluation. Although differences between single and multiple TBI groups were observed, these did not reach the level of statistical significance. A history of any TBI increased the likelihood of current TBI diagnosis, but this relationship was no longer significant when adjusting for injury mechanism, depression and post-traumatic stress symptoms. Conclusion: Among deployed military personnel, the relationship of previous TBI with recent TBI and concussive symptoms may be largely explained by the presence of psychological symptoms.

关键词： Concussion depression PTSD TBI

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depression in older patients with advanced colorectal cancer is closely connected with immunosuppressive acidic protein

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METABOLIC BRAIN DISEASE 2014年第1期29卷 87-92页

作者： Li, Rong Yang, Jie Yang, Jihua Fu, Weijun Jiang, Hua Du, Juan Zhang, Chunyang Xi, Hao Hou, Jian Second Mil Med Univ Chang Zheng Hosp Dept Hematol Myeloma & Lymphoma Ctr Shanghai 200003 Peoples R China Shanghai Blood Ctr Blood Engn Lab Shanghai Peoples R China Fudan Univ Huashan Hosp Div Rheumatol Shanghai Peoples R China Fudan Univ Huashan Hosp Div Rheumatol Shanghai 200433 Peoples R China Peoples Liberat Army Gen Hosp Dept Med Oncol Beijing Peoples R China

Colorectal cancer (CRC) is one of the most common tumors. CRC patients are susceptible to suffering from depression. Whether the immune system of CRC patients with depression is impaired or stimulated is controversial. Possible reasons for this conflict are the involvement of confounding factors, such as the age of the patient, the stage of the CRC and the types of treatment in previous studies. To demonstrate clearly the relationship between depression and the immune system in the context of CRC, the present study included only older patients with advanced CRC who received only chemotherapy, and the study adopted immunosuppressive acidic protein (IAP) as an immune parameter for the first time. A total of 56 older patients with advanced CRC completed the Zung Self-Rating depression Scale (SDS) and were divided into two groups according to SDS scores. The patients exhibiting depression were treated with fluoxetine until their symptoms remitted. The serum levels of IAP and the percentages of CD3-positive (CD3+), CD4+, CD8+ T lymphocytes and CD56+ natural killer (NK) cells and Neutrophil-lymphocyte ratio (NLR) were calculated at the time of enrollment and once the symptoms remitted. Correlation analyses revealed that the SDS score was positively associated with serum IAP levels but negatively associated with CD3 and CD4 levels. Among the depressed and non-depressed patients, serum IAP levels and the percentages of CD3 and CD4 cells were dramatically different. After the depression symptoms were treated, the IAP levels dramatically decreased, while the levels of CD3, CD4, CD8 and CD56 were unchanged. All of above suggested that IAP was closely correlated with depression and might be a relatively objective parameter for predicting depression.

关键词： depression Immunosuppressive acid protein Immunity Colorectal cancer Older patient Neutrophil-lymphocyte ratio

来源： ebsco(ASP/aph)

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