"Low-intensity ultrasound promotes uterine involution after cesarean section: the first multicenter, randomized, controlled clinical trial"

作者全名："Qin, Yi; Zhao, Xiaobo; Dong, Xiaojing; Liu, Juntao; Wang, Longqiong; Wu, Xiaohua; Peng, Bin; Li, Chengzhi"

作者地址："[Qin, Yi; Li, Chengzhi] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Coll Biomed Engn, Chongqing 400016, Peoples R China; [Qin, Yi; Li, Chengzhi] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China; [Zhao, Xiaobo] Shanghai First Matern & Infant Hosp, Shanghai, Peoples R China; [Dong, Xiaojing] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China; [Liu, Juntao] Peking Union Med Coll Hosp, Beijing, Peoples R China; [Wang, Longqiong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Wu, Xiaohua] Army Med Univ, Xinqiao Hosp, Chongqing, Peoples R China; [Peng, Bin] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Hlth Stat, Chongqing, Peoples R China"

通信作者："Li, CZ (通讯作者)，Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Coll Biomed Engn, Chongqing 400016, Peoples R China.; Li, CZ (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000742210400001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：39

期号：1

开始页：181

结束页：189

文献类型：Article

关键词：LIUS; uterine involution; fundal height; lochia; postpartum pain

摘要："Objective To evaluate the clinical efficacy and safety of low-intensity ultrasound (LIUS) in promoting uterine involution and relieving postpartum pain. Methods The randomized controlled clinical trial in this study was conducted at five centers in three regions across China from June 2014 to December 2014. A total of 498 subjects were randomly divided into two groups. The LIUS group received ultrasound treatment, and the control group received sham ultrasound treatment. The fundal height and visual analogue scale (VAS) scores of the subjects following cesarean section were recorded separately before and after five treatments. The incidence of adverse events was recorded, while the records on lochia duration were obtained by telephone follow-up. The Full Analysis Set (FAS) comprised all subjects randomized who received at least one treatment. The Per-Protocol Set (PPS) comprised all patients who did not seriously violate the study protocol and had good compliance with complete report forms. Efficacy analyses were performed based on the FAS and PPS. All safety analyses were performed based on the safety set (SS), which included all patients who received at least one treatment. Results In the analysis of PPS and FAS, the LIUS group performed better than the control group in reducing the fundal height, shortening the duration of lochia, and relieving postpartum pain, with a significant difference between the two groups (p < 0.0001). In the SS analysis, there were no treatment-related adverse events observed in either group. Conclusions The LIUS therapy is safe and effective, which contributes to uterine involution and the alleviation of postpartum pain."

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