Retinal microglia: Functions and diseases
作者全名："Fan, Wei; Huang, Weidi; Chen, Jiayi; Li, Na; Mao, Liming; Hou, Shengping"
作者地址："[Fan, Wei; Huang, Weidi; Chen, Jiayi; Hou, Shengping] Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Fan, Wei; Hou, Shengping] Chongqing Key Lab Ophthalmol, Chongqing, Peoples R China; [Fan, Wei; Hou, Shengping] Chongqing Eye Inst, Chongqing, Peoples R China; [Fan, Wei; Hou, Shengping] Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China; [Huang, Weidi] Cent South Univ, Dept Ophthalmol, Xiangya Hosp 2, Changsha, Peoples R China; [Li, Na] Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China; [Mao, Liming] Nantong Univ, Dept Immunol, Sch Med, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China"
通信作者："Hou, SP (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Li, N (通讯作者)，Chongqing Med Univ, Coll Basic Med, Chongqing 400016, Peoples R China.; Mao, LM (通讯作者)，Nantong Univ, Dept Immunol, Sch Med, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China."
来源：IMMUNOLOGY
ESI学科分类：IMMUNOLOGY
WOS号：WOS:000784499500001
JCR分区：Q2
影响因子：6.4
年份：2022
卷号：166
期号：3
开始页：268
结束页：286
文献类型：Review
关键词：microglial function; microglial transdifferentiation; retinal degeneration; retinal disease; retinal microglia
摘要："Microglia, the resident immune cells in the retina and nervous system, make irreplaceable contributions to the maintenance of normal homeostasis and immune surveillance of these systems. Recently, great progress has been made in determining the origin, distribution, features and functions of retinal microglia and in identifying their roles in retinal diseases. In the retinal microenvironment, microglia constantly monitor changes in their surroundings and maintain balanced functions by communicating with other retinal cells. When disturbed, activated microglia may kill degenerated neurons and photoreceptors through phagocytosis and exacerbate retinal injury by producing multiple proinflammatory mediators. Numerous animal studies and in situ analyses of human tissue have shown that retinal microglia are involved in multiple retinal diseases. The functions and mechanisms of activated microglia in retinal disorders are gradually being elucidated. Increasing evidence points towards the dual roles of microglia in the retina and they are regulated by many factors. How to inhibit the detrimental effects of microglia and promote beneficial effects are worth studying. This review focuses primarily on the features and functions of microglia and how they participate in retinal diseases based on existing research findings. We also discuss current opinions about microglial transdifferentiation."
基金机构："National Natural Science Foundation Project of China [81 873 678, 82 070 951, 32 070 919]; Innovative Research Group Project of Chongqing Education Commission [CXQT19015]; Natural Science Foundation Project of Chongqing [cstc2019jcyjmsxmX0120]; innovation supporting Plan of Overseas Study of Chongqing [cx2018010]; National Key Clinical Specialties Construction Program of China; Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing Key Laboratory of Ophthalmology (CSTC) [2008CA5003]; Natural Science Foundation of Jiangsu Province [BK20201442]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [0047]"
基金资助正文："This work was supported by National Natural Science Foundation Project of China (81 873 678, 82 070 951, 32 070 919), The Innovative Research Group Project of Chongqing Education Commission (CXQT19015), Natural Science Foundation Project of Chongqing (cstc2019jcyjmsxmX0120), the innovation supporting Plan of Overseas Study of Chongqing (cx2018010) and National Key Clinical Specialties Construction Program of China, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003) and Natural Science Foundation of Jiangsu Province (BK20201442), Program for Youth Innovation in Future Medicine, Chongqing Medical University (0047)"
